Cadrofloxacin (hydrochloride)  (Synonyms: Caderofloxacin (hydrochloride); CS-940 (hydrochloride))

Cadrofloxacin (Caderofloxacin; CS-940) hydrochloride is an orally active antibacterial agent with significant bactericidal activity against quinolone-resistant Staphylococcus aureus, Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria. Cadrofloxacin hydrochloride effectively improves systemic infection and experimental Klebsiella pneumoniae pneumonia in mice. Cadrofloxacin hydrochloride can be widely used in research related to systemic bacterial infections and bacterial pneumonia^[1].

Cadrofloxacin hydrochloride (0.006-25 μg/mL; 18 h-48 h) exhibits broad-spectrum in vitro antibacterial activity against clinical isolates of gram-positive, gram-negative, anaerobic, Salmonella, Shigella, and Neisseria spp., with notably enhanced activity against methicillin-resistant and quinolone-resistant S. aureus (MIC₉₀ = 12.5 μg/mL and 25 μg/mL, respectively)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cadrofloxacin (hydrochloride) (0.0035-0.98 mg/mouse; p.o.; single dose; 2 hours post-infection) exhibits potent in vivo protective activity against 8 bacterial systemic infections in mice, with ED₅₀ values ranging from 0.0035 to 0.98 mg/mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

447.84

C₁₉H₂₁ClF₃N₃O₄

128427-55-4

FC(F)OC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@H](NCC4)C)=O)C(O)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Masuda N, et al. In vitro and in vivo antibacterial activities of CS-940, a new 6-fluoro-8-difluoromethoxy quinolone[J]. Antimicrobial agents and chemotherapy, 1996, 40(5): 1201-1207.