Cadrofloxacin (hydrochloride)
Cadrofloxacin (Caderofloxacin; CS-940) hydrochloride is an orally active antibacterial agent with significant bactericidal activity against quinolone-resistant Staphylococcus aureus, Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria. Cadrofloxacin hydrochloride effectively improves systemic infection and experimental Klebsiella pneumoniae pneumonia in mice. Cadrofloxacin hydrochloride can be widely used in research related to systemic bacterial infections and bacterial pneumonia.
For research use only. We do not sell to patients.
- CAS No.: 128427-55-4
- Formula: C19H21ClF3N3O4
- Molecular Weight:447.84
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Cadrofloxacin hydrochloride (0.006-25 μg/mL; 18 h-48 h) exhibits broad-spectrum in vitro antibacterial activity against clinical isolates of gram-positive, gram-negative, anaerobic, Salmonella, Shigella, and Neisseria spp., with notably enhanced activity against methicillin-resistant and quinolone-resistant S. aureus (MIC90 = 12.5 μg/mL and 25 μg/mL, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ddY mice (male, ~20 g, intraperitoneally infected with bacterial strains)[1]
-
Dosage:0.0035-0.98 mg/mouse
-
Administration:p.o.; single dose; 2 hours post-infection
-
Result:Achieved an ED50 of 0.016 mg/mouse against S. aureus Smith.
Achieved an ED50 of 0.18 mg/mouse against quinolone-resistant S. aureus QR-51.
Achieved an ED50 of 0.98 mg/mouse against S. pneumoniae type III.
Achieved an ED50 of 0.44 mg/mouse against S. pyogenes C-203.
Achieved an ED50 of 0.0035 mg/mouse against E. coli KC-14.
Achieved an ED50 of 0.012 mg/mouse against K. pneumoniae KC-1.
Achieved an ED50 of 0.074 mg/mouse against S. marcescens T-55.
Achieved an ED50 of 0.076 mg/mouse against P. aeruginosa E-2.
Chemical Information
-
CAS No. 128427-55-4
-
Molecular Weight 447.84
-
Formula C19H21ClF3N3O4
-
SMILES
FC(F)OC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@H](NCC4)C)=O)C(O)=O.Cl
-
Synonyms
Caderofloxacin (hydrochloride); CS-940 (hydrochloride)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cadrofloxacin (hydrochloride) Related Classifications
HY-116228A Related Classifications
Powered by Bioz