1133421-35-8
Chemical Structure
Alogliptin-d3
Synonym(s): SYR-322-d3 free base
- CAS No.: 1133421-35-8
- Formula:C18H18D3N5O2
- Molecular Weight:342.41
IUPAC Name: (R)-2-((6-(3-aminopiperidin-1-yl)-3-(methyl-d3)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
InChIKey: ZSBOMTDTBDDKMP-DDOHFVCQSA-N
SMILES: O=C(N(C1=O)C([2H])([2H])[2H])C=C(N2C[C@@H](CCC2)N)N1CC3=C(C=CC=C3)C#N
Biological Activity: Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alogliptin-d3 | 99.61% | Alogliptin-d3 is the deuterium labeled Alogliptin. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes. | ||||||||||||||||||||
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Alogliptin (Standard) | ≥98% | Alogliptin (Standard) is the analytical standard of Alogliptin. This product is intended for research and analytical applications. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes. | ||||||||||||||||||||
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Alogliptin-13C,d3 | Alogliptin-13C,d3 is the deuterium labeled Alogliptin. Alogliptin is a potent and selective inhibitor of DPP-4. | |||||||||||||||||||||
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Alogliptin-13C,d3 benzoate | 98.77% | Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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Alogliptin | 99.93% | Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Feng J, et al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300. [Content Brief]
- [3]. Ta NN, et al. DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis. 2010 Dec;213(2):429-35. [Content Brief]
