21288-60-8
21288-60-8
Chemical Structure
ε-Rhodomycinone
- CAS No.: 21288-60-8
- Formula:C22H20O9
- Molecular Weight:428.39
InChIKey: PYFOXRACBORDCT-GOSXWKPOSA-N
SMILES: COC([C@@H]1C2=C([C@H](C[C@]1(O)CC)O)C(O)=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C2O)=O
Biological Activity: ε-Rhodomycinone is a bacterial metabolite found in S. griseoruber. It is a precursor to Rhodomycin D, which is an intermediate in the bioconversion of ε-rhodomycinone to Daunorubicin (HY-13062) and Doxorubicin (HY-15142R)[1][2][3].
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ε-Rhodomycinone | ε-Rhodomycinone is a bacterial metabolite found in S. griseoruber. It is a precursor to Rhodomycin D, which is an intermediate in the bioconversion of ε-rhodomycinone to Daunorubicin (HY-13062) and Doxorubicin (HY-15142R). | |||||||||||||||||||||
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References
- [1]. Podojil M, et al. Production of rhodomycins in Streptomyces griseoruber 4620. Folia Microbiol (Praha). 1980;25(6):464-6. [Content Brief]
- [2]. Olano C, et al. A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D. Chem Biol. 1999 Dec;6(12):845-55. [Content Brief]
- [3]. Dickens ML, et al. In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA. J Bacteriol. 1997 Apr;179(8):2641-50. [Content Brief]
Keywords
