ε-Rhodomycinone
ε-Rhodomycinone is a bacterial metabolite found in S. griseoruber. It is a precursor to Rhodomycin D, which is an intermediate in the bioconversion of ε-rhodomycinone to Daunorubicin (HY-13062) and Doxorubicin (HY-15142R).
For research use only. We do not sell to patients.
- CAS No.: 21288-60-8
- Formula: C22H20O9
- Molecular Weight:428.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
9.6 μM
Compound: 14
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Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
|
[PMID: 29767975] |
| HepG2 | IC50 |
13.5 μM
Compound: 14
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Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
|
[PMID: 29767975] |
| MCF-10A | IC50 |
7.1 μM
Compound: 14
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Cytotoxicity against human MCF10A cells after 48 hrs by MTT assay
Cytotoxicity against human MCF10A cells after 48 hrs by MTT assay
|
[PMID: 29767975] |
| MDA-MB-231 | IC50 |
13.2 μM
Compound: 14
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
|
[PMID: 29767975] |
| MDA-MB-435 | IC50 |
9.2 μM
Compound: 14
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Cytotoxicity against human MDA-MB-435 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells after 48 hrs by MTT assay
|
[PMID: 29767975] |
| NCI-H460 | IC50 |
10 μM
Compound: 14
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Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
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[PMID: 29767975] |
Chemical Information
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CAS No. 21288-60-8
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Molecular Weight 428.39
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Formula C22H20O9
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SMILES
COC([C@@H]1C2=C([C@H](C[C@]1(O)CC)O)C(O)=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C2O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Podojil M, et al. Production of rhodomycins in Streptomyces griseoruber 4620. Folia Microbiol (Praha). 1980;25(6):464-6. [Content Brief]
[2]. Olano C, et al. A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D. Chem Biol. 1999 Dec;6(12):845-55. [Content Brief]
[3]. Dickens ML, et al. In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA. J Bacteriol. 1997 Apr;179(8):2641-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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