2609-46-3
2609-46-3
Chemical Structure
Amiloride
Synonym(s): MK-870
- CAS No.: 2609-46-3
- Formula:C6H8ClN7O
- Molecular Weight:229.63
IUPAC Name: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
InChIKey: XSDQTOBWRPYKKA-UHFFFAOYSA-N
SMILES: O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N
Biological Activity: Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Amiloride | 99.96% | Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Amiloride (Standard) | 99.82% | Amiloride (Standard) is the analytical standard of Amiloride. This product is intended for research and analytical applications. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Amiloride-15N3 | Amiloride-15N3 (MK-870-15N3) is 15N labeled Amiloride. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.90
HY-1550176-Iodoamiloride -
Similarity Score 0.72
HY-W5443763,6-Diaminopyrazine-2,5-dicarboxylic acid -
Similarity Score 0.69
HY-W343043Pyrazinoylguanidine -
Similarity Score 0.68
HY-W539745R2,4,6-Triamino-5-nitrosopyrimidine (Standard) -
Similarity Score 0.67
HY-W076339R5,6-Dichloropyrimidine-2,4-diamine (Standard) -
Similarity Score 0.65
HY-D10612,4,5,6-Tetraaminopyrimidine -
Similarity Score 0.64
HY-W008484Aminopyralid -
Similarity Score 0.64
HY-B0271SPyrazinamide-d3 -
Similarity Score 0.63
HY-Z3477Sorafenib impurity 5 -
Explore the MedChemAI to find more analogs
References
- [1]. Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26. [Content Brief]
- [2]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17. [Content Brief]
- [3]. Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. [Content Brief]
