3327-24-0
Chemical Structure
2'-Hydroxy-4-methoxychalcone
- CAS No.: 3327-24-0
- Formula:C16H14O3
- Molecular Weight:254.28
IUPAC Name: (E)-1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
InChIKey: NXBNYUSXDBHELA-DHZHZOJOSA-N
SMILES: O=C(C1=CC=CC=C1O)/C=C/C2=CC=C(OC)C=C2
Biological Activity: 2'-Hydroxy-4-methoxychalcone is a PPARγ agonist. 2'-Hydroxy-4-methoxychalcone also exhibits inhibitory activity against gelatinase/collagenase and human glutathione S-transferase (GST), with an IC50 of 5.2 μM and a Ki of 15.36 μM against GST. 2'-Hydroxy-4-methoxychalcone inhibits both the NF-κB and AP-1 signaling pathways, exerting anti-inflammatory activity; it also inhibits COX-2, conferring anti-cancer/anti-angiogenic activity. 2'-Hydroxy-4-methoxychalcone can be used in studies related to atherosclerosis, inflammatory diseases and cancer[1][2][3][4].
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2'-Hydroxy-4-methoxychalcone | 2'-Hydroxy-4-methoxychalcone is a PPARγ agonist. 2'-Hydroxy-4-methoxychalcone also exhibits inhibitory activity against gelatinase/collagenase and human glutathione S-transferase (GST), with an IC50 of 5.2 μM and a Ki of 15.36 μM against GST. 2'-Hydroxy-4-methoxychalcone inhibits both the NF-κB and AP-1 signaling pathways, exerting anti-inflammatory activity; it also inhibits COX-2, conferring anti-cancer/anti-angiogenic activity. 2'-Hydroxy-4-methoxychalcone can be used in studies related to atherosclerosis, inflammatory diseases and cancer. | |||||||||||||||||||||
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- [1]. Lee YS, et al. Anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone. Biological & pharmaceutical bulletin. 2006 May;29(5):1028-31. [Content Brief]
- [2]. Liu CS, et al. 2-hydroxy-4'-methoxychalcone inhibits proliferation and inflammation of human aortic smooth muscle cells by increasing the expression of peroxisome proliferator-activated receptor gamma. Journal of cardiovascular pharmacology. 2012 Apr;59(4):339-51. [Content Brief]
- [3]. Ban HS, et al. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells. Biochemical pharmacology. 2004 Apr 15;67(8):1549-57. [Content Brief]
- [4]. Özaslan MS, et al. Evaluation of chalcones as inhibitors of glutathione S-transferase. Journal of biochemical and molecular toxicology. 2018 May;32(5):e22047. [Content Brief]
Keywords
