5369-00-6
5369-00-6
Chemical Structure
QX-222 chloride
- CAS No.: 5369-00-6
- Formula:C13H21ClN2O
- Molecular Weight:256.77
IUPAC Name: 2-((2,6-dimethylphenyl)amino)-N,N,N-trimethyl-2-oxoethan-1-aminium chloride
InChIKey: WFKXSWWTOZBDME-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C)C=CC=C1C)C[N+](C)(C)C.[Cl-]
Biological Activity: QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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QX-222 chloride | 96.31% | QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker. | ||||||||||||||||||||
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QX-222 chloride (Standard) | ≥98% | QX-222 (chloride) (Standard) is the analytical standard of QX-222 (chloride) (HY-101362). This product is intended for research and analytical applications. QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker. | ||||||||||||||||||||
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References
- [1]. A Sunami, et al. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2326-31. [Content Brief]
- [2]. Qingmin Chen, et al. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. J Pain. 2004 Jun;5(5):281-9. [Content Brief]
- [3]. J A Flatman, et al. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222. J Neurophysiol. 1982 Aug;48(2):419-30. [Content Brief]
