1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. QX-222 chloride

QX-222 chloride 

Cat. No.: HY-101362 Purity: 96.09%
Handling Instructions

QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker.

For research use only. We do not sell to patients.

QX-222 chloride Chemical Structure

QX-222 chloride Chemical Structure

CAS No. : 5369-00-6

Size Price Stock Quantity
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker[1][2][3].

In Vitro

Twelve minutes after external application of 500 μM QX222 chloride, μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

QX-222 (10 mg/kg; intravenous infusion 7 days) chloride reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

256.77

Formula

C13H21ClN2O

CAS No.
SMILES

O=C(NC1=C(C)C=CC=C1C)C[N+](C)(C)C.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (486.82 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8945 mL 19.4727 mL 38.9454 mL
5 mM 0.7789 mL 3.8945 mL 7.7891 mL
10 mM 0.3895 mL 1.9473 mL 3.8945 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.10 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
QX-222 chloride
Cat. No.:
HY-101362
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