5989-02-6
Chemical Structure
Loliolide
Synonym(s): Loliolid; Digiprolactone
- CAS No.: 5989-02-6
- Formula:C11H16O3
- Molecular Weight:196.24
IUPAC Name: (6S,7aR)-6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one
InChIKey: XEVQXKKKAVVSMW-WRWORJQWSA-N
SMILES: C[C@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O
Biological Activity: Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Loliolide | 99.92% | Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease. | ||||||||||||||||||||
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References
- [1]. Park SH, et al. Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes. Int J Mol Sci. 2019;20(3):651. Published 2019 Feb 2. [Content Brief]
- [2]. Silva J, et al. Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum. Int J Mol Sci. 2021;22(4):1888. Published 2021 Feb 14. [Content Brief]
- [3]. Murata M, et al. Loliolide, a Carotenoid Metabolite, Is a Potential Endogenous Inducer of Herbivore Resistance. Plant Physiol. 2019;179(4):1822-1833. [Content Brief]
