2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Ceefourin 2

Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability.

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Ceefourin 2

Ceefourin 2 Chemical Structure

CAS No. : 348148-51-6

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Ceefourin 2 Related Antibodies

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Description

Ceefourin 2 is a potent and highly selective inhibitor of MRP4. Ceefourin 2 inhibits the transport of MRP4 substrates but is not selective for other ABC transporters. Ceefourin 2 shows lower cytotoxicity and higher microsomal and acid stability[1].

In Vitro

Ceefourin 2 is highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (ABCC1). Ceefourin 2 has limited off-target effects and high stability[1].
Ceefourin 2 (100 nM-100 μM) has low cellular toxicity (IC50 >50 μM) in two normal (HSF, MRC5), five neuroblastoma (BE(2)-C, IMR-32, IMR-32, SK-N-SH, SHEP) and four other human cancer cell lines (HEPG2, LNCap, SJ-G2, MCF7)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ceefourin 2 Related Antibodies
Molecular Weight

355.70

Formula

C15H9ClF3N3O2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(O)C1=NN2C(C(F)(F)F)=CC(C3=CC=C(C=C3)C)=NC2=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Ceefourin 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceefourin 2348148-51-6Ceefourin2Ceefourin-2P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243HEPG2LNCapSJ-G2MCF7Inhibitorinhibitorinhibit

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Ceefourin 2
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