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Art. -Nr.: HY-P1515

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Angiotensin II (3-8), human

2 Cited Publications

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Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT₁ receptor.

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CAS. Nr.: 12676-15-2
Formel: C₄₀H₅₄N₈O₈
Molecular Weight:774.91

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Angiotensin II (3-8), human Chemical Structure

CAS. Nr.: 12676-15-2

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Biologische Aktivität
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- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
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Biologische Aktivität

Beschreibung

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT₁ receptor.

IC₅₀ & Target

Angiotensin AT₁ receptor^[1]

Alle Angiotensin Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 12676-15-2
Molecular Weight 774.91
Formel C₄₀H₅₄N₈O₈
Sequence

Val-Tyr-Ile-His-Pro-Phe
Sequence Shortening

VYIHPF
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Theranostics

Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis. [Abstract]

2021 Jul 25;11(18):8624-8639. PMID: 34522203
Eur J Pharmacol

Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. [Abstract]

2019 Jun 15:853:93-102. PMID: 30878387

Protokoll

Animal Administration^[1]

Rats^[1]
Male Long Evans rats (350-450 g) (n=7) are given increasing bolus doses of AII (1.25, 12.5 and 125 pmol/kg) or human Angiotensin II (3-8) (0.125, 1.25 and 12.5 nmol/kg) in random order, in the morning or afternoon of the same experimental day. Injections are separated by at least 20 min to allow variables to return to baseline^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gardiner SM, et al. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol. 1993 Sep;110(1):159-62. [Content Brief]

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

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Keywords

Angiotensin II (3-8), human

2 Cited Publications

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Biologische Aktivität
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- IC₅₀ & Target
- In Vivo
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Publications (2)
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Angiotensin II (3-8), human

Publications Citing Use of MedChemExpress (MCE) Angiotensin II (3-8), human

Alle Angiotensin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

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Reinheit & Dokumentation

Verweise

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Help & FAQs

Angiotensin II (3-8), human Related Classifications

HY-P1515 Related Classifications