ABT-510 acetate
Based on 1 publication(s) in Google Scholar
ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD).
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- Reinheit: 99.84%
- CAS. Nr.: 442526-87-6
- Formel: C48H87N13O13
- Molecular Weight:1054.28
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Speicherung:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ABT-510 acetate
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Biologische Aktivität
ABT-510 acetate (1, 5, 10, 20, 50 nM; 24 h) induces apoptosis in ID8 cells and increases the incidence of apoptosis in the human epithelial cancer cell lines SKOV3, OVCAR3, and CAOV3[1].
ABT-510 acetate (0-10 μM; 7 days) inhibits NO-stimulated vascular cell outgrowth into and invasion through extracellular matrix. ABT-510 acetate blocks tumor-driven vascular cell outgrowth, NO-driven cGMP flux, and CD36-mediated fatty acid uptake. [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ID8, SKOV3, OVCAR3, and CAOV3 cells
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Concentration:1, 5, 10, 20, 50 nM
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Incubation Time:24 h
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Result:Induced ID8 cells apoptosis and increased in apoptosis in the human EOC cell lines SKOV3, OVCAR3, and CAOV3.
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Cell Line:Tissue biopsies of B16F10 melanoma tumors grown in C57BL/6 mice
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Concentration:0-10 μM
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Incubation Time:7 days
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Result:Inhibited NO-stimulated vascular cell outgrowth into and invasion through extracellular matrix.
ABT-510 acetate (60 mg/kg; osmotic minipumps for s.c.; single daily for 7 days) decreases angiogenesis and inflammation in a murine model of inflammatory bowel disease[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:TSP-1-Null mice (C57BL/6 background; orthotopic, syngeneic model of epithelial ovarian cancer)[1]
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Dosage:100 mg/kg
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Administration:Intraperitoneal injection; single daily for 90 days
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Result:Reduced ovarian tumor growth in wild-type and TSP-1-Null Mice.
Significantly reduced the volume of ascites and completely abolished the formation of peritoneal lesions.
Reversed ovarian tumor hypervascularization and increased the proportion of mature blood vessels.
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Animal Model:TSP-1-Null mice (C57BL/6 background; 6-week-old; DSS-induced inflammatory bowel disease murine model)[2]
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Dosage:60 mg/kg
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Administration:Subcutaneously implanted osmotic minipumps (0.5µL/h); single daily for 7 days
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Result:Significantly delayed DSS-induced bleeding and improved the overall severity of disease.
Significantly diminished inflammation grading and angiogenesis.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 442526-87-6
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Appearance Solid
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Molecular Weight 1054.28
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Formel C48H87N13O13
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Color White to off-white
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Sequence
Ac-{Sar}-Gly-Val-{D-Ile}-Thr-{Nva}-Ile-Arg-{Pro-NHEt}
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Sequence Shortening
Ac-{Sar}-GV-{D-Ile}-T-{Nva}-IR-{Pro-NHEt}
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Truncated thrombospondin-1 polypeptide alleviates non-alcoholic fatty liver disease induced by palmitic acid and high-fat diets. [Abstract]2025 Oct 17;331(Pt 1):148308. PMID: 41109376
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (94.85 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Greenaway J, et.al. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8(1):64-74. [Content Brief]
[2]. Punekar S,et.al. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology. 2008;75(1):9-21. [Content Brief]
[3]. Isenberg JS, et.al. Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells. Biochem Pharmacol. 2008 Feb 15;75(4):875-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9485 mL | 4.7426 mL | 9.4851 mL | 23.7129 mL |
| 5 mM | 0.1897 mL | 0.9485 mL | 1.8970 mL | 4.7426 mL | |
| 10 mM | 0.0949 mL | 0.4743 mL | 0.9485 mL | 2.3713 mL | |
| 15 mM | 0.0632 mL | 0.3162 mL | 0.6323 mL | 1.5809 mL | |
| 20 mM | 0.0474 mL | 0.2371 mL | 0.4743 mL | 1.1856 mL | |
| 25 mM | 0.0379 mL | 0.1897 mL | 0.3794 mL | 0.9485 mL | |
| 30 mM | 0.0316 mL | 0.1581 mL | 0.3162 mL | 0.7904 mL | |
| 40 mM | 0.0237 mL | 0.1186 mL | 0.2371 mL | 0.5928 mL | |
| 50 mM | 0.0190 mL | 0.0949 mL | 0.1897 mL | 0.4743 mL | |
| 60 mM | 0.0158 mL | 0.0790 mL | 0.1581 mL | 0.3952 mL | |
| 80 mM | 0.0119 mL | 0.0593 mL | 0.1186 mL | 0.2964 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
ABT-510 acetate Related Classifications
HY-13545B Related Classifications
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