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Art. -Nr.: HY-155557

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Anti-inflammatory agent 45

Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers including leukemia, lymphoma and myeloma cell lines. Anti-inflammatory agent 45 induces apoptosis and inhibits NO production in HL60 leukemia cells (IC₅₀=14.7 μM).

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CAS. Nr.: 3053681-79-8
Formel: C₂₅H₂₂BrNO₆
Molecular Weight:512.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Anti-inflammatory agent 45 Chemical Structure

CAS. Nr.: 3053681-79-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	14.7 μM Compound: 2v	Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed stimulated with LPS for 22 hrs by Griess reaction assay Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed stimulated with LPS for 22 hrs by Griess reaction assay	[PMID: 37354740]
BV-2	IC₅₀	9.1 μM Compound: 2v	Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 2 hrs followed stimulated with LPS for 22 hrs Anti-inflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced PGE2 production pretreated for 2 hrs followed stimulated with LPS for 22 hrs	[PMID: 37354740]
CCRF-CEM	GI₅₀	2.62 μM Compound: 2v	Anticancer activity against human CCRF-CEM cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control Anticancer activity against human CCRF-CEM cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control	[PMID: 37354740]
HL-60	GI₅₀	1.64 μM Compound: 2v	Anticancer activity against human HL-60 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control Anticancer activity against human HL-60 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control	[PMID: 37354740]
K562	GI₅₀	1.42 μM Compound: 2v	Anticancer activity against human K562 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control Anticancer activity against human K562 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control	[PMID: 37354740]
MOLT-4	GI₅₀	1.63 μM Compound: 2v	Anticancer activity against human MOLT-4 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control Anticancer activity against human MOLT-4 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control	[PMID: 37354740]
RPMI-8226	GI₅₀	1.58 μM Compound: 2v	Anticancer activity against human RPMI-8226 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control Anticancer activity against human RPMI-8226 cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control	[PMID: 37354740]
SR	GI₅₀	1.34 μM Compound: 2v	Anticancer activity against human SR cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control Anticancer activity against human SR cells assessed as growth inhibition measured after 48 hrs by SRB assay relative to control	[PMID: 37354740]

Chemical Information

CAS. Nr. 3053681-79-8
Molecular Weight 512.35
Formel C₂₅H₂₂BrNO₆
SMILES

BrC1=CC=C(C(NC2=CC(C(C3)OC4=CC(OC)=C(OC)C(OC)=C4C3=O)=CC=C2)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hassan AHE, et al. Design, synthesis, and evaluation of new anti-inflammatory natural products amide derivatives endowed with anti-blood cancer activity towards development of potential multifunctional agents against hematological cancers. Eur J Med Chem. 2023 Oct 5;258:115566. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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