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Art. -Nr.: HY-182049

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Antibacterial agent 332

Antibacterial agent 332 is an inhibitor of DsbA from Escherichia coli (EcDsbA). Antibacterial agent 332 reduces the swarming motility of Escherichia coli without affecting bacterial growth. Antibacterial agent 332 can be used in the research of bacterial infections caused by Escherichia coli.

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CAS. Nr.: 3106820-05-4
Formel: C₂₆H₂₃F₂N₃O₆
Molecular Weight:511.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 332 Chemical Structure

CAS. Nr.: 3106820-05-4

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antibacterial agent 332 (compound 17) (0-100 mM) binds to histidine-tagged E. coli DsbA, with a kinetic SPR K_D of 2.2 μM and an equilibrium SPR K_D of 2.8 μM^[1].
Antibacterial agent 332 (50 μM; 180 s injection intervals) binds to Escherichia coli DsbA, with an ITC K_D value of 1.5 μM determined based on the single-site binding model^[1].
Antibacterial agent 332 inhibits Escherichia coli DsbA-mediated oxidation of native peptide substrates with an IC₅₀ of 30 μM in peptide oxidation assays^[1].
Antibacterial agent 332 (1 h, room temperature) shows a high enrichment rate in ASMS screening, indicating that it can form a stable complex with E. coli DsbA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3106820-05-4
Molecular Weight 511.47
Formel C₂₆H₂₃F₂N₃O₆
SMILES

FC1=CC(C[C@@H](CO)NC(C#CC2=CC(NC(C3=NOC(C)=C3)=O)=CC=C2)=O)=CC(F)=C1CC(OC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Tasdan Y, et al. Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening. J Med Chem. 2026;69(6):6760-6774. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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