Art. -Nr.: HY-118742

Benzobicyclon

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Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds.

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Reinheit: 98.76%
CAS. Nr.: 156963-66-5
Formel: C₂₂H₁₉ClO₄S₂
Molecular Weight:446.97

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Benzobicyclon Chemical Structure

CAS. Nr.: 156963-66-5

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

4-HPPD^[1]

In Vitro

Benzobicyclon (100-300 g a.i./ha; 1 L or 2 L) exhibits excellent herbicidal activity against S. juncoides regardless of the emergence depth between 0 and 3 cm and (200-300 g a.i./ha; pre-emergence; 1 L) hardly affected by the soil types^[1].
Benzobicyclon (300 g a.i./ha; 1-leaf and 1 L stages) completely controls S. juncoides at 25°C, 20°C, and 15°C, and takes longer to reach 90% control at low temperatures^[1].
Benzobicyclon (200, 300 g a.i./ha; pre-emergence and 1 L stages) exhibits excellent herbicidal activity against all SU-R biotypes S. juncoides, M. vaginalis and L. dubia as well as SU-S biotypes. (SU-S: sulfonylurea herbicide-susceptible, SU-R: sulfonylurea herbicide-resistant)^[1].
Benzobicyclon (200-600 g a.i./ha; pre-emergence and 1 L stages) exhibits excellent herbicidal activity against E. crus-galli , S. juncoides, M. vaginalis, L. var. dubia and C. serotinus and shows good rice crop safety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

S. juncoides
Concentration:

200, 300 g a.i./ha
Incubation Time:

pre-emergence and 1 L stages
Result:

Completely controlled S. juncoides in 5 types of paddy soils, namely, clay loam, loam, light clay, sandy loam, and heavy clay.

Cell Viability Assay^[1]

Cell Line:

S. juncoides
Concentration:

300 g a.i./ha
Incubation Time:

1-leaf and 1 L stages
Result:

Showed 90% control at 25°C, 20°C, and 15°C at 14, 22, and 32 days after application, respectively.

Cell Viability Assay^[1]

Cell Line:

S. juncoides, M. vaginalis, L. dubia
Concentration:

200, 300 g a.i./ha
Incubation Time:

Pre-emergence and 1 L stages
Result:

Showed good herbicidal activity against all SU-R biotypes tested as well as SU-susceptible biotypes.

Cell Viability Assay^[1]

Cell Line:

Transplanted rice (3 cm)
Concentration:

200-600 g a.i./ha
Incubation Time:

Pre-emergence and 1 L stages
Result:

Exhibited excellent herbicidal activity and broad-herbicidal spectrum without causing injury to transplanted rice.

Chemical Information

CAS. Nr. 156963-66-5
Appearance Solid
Molecular Weight 446.97
Formel C₂₂H₁₉ClO₄S₂
Color Light yellow to brown
SMILES

O=C1C2CC(C(SC3=CC=CC=C3)=C1C(C4=CC=C(C=C4Cl)S(=O)(C)=O)=O)CC2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 16.67 mg/mL (37.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2373 mL

11.1864 mL

22.3729 mL

5 mM

0.4475 mL

2.2373 mL

4.4746 mL

10 mM

0.2237 mL

1.1186 mL

2.2373 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.67 mg/mL (3.74 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.67 mg/mL (3.74 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (562 KB)
- English - EN (562 KB)
- Français - FR (562 KB)
- Deutsch - DE (562 KB)
- Norwegian - NO (562 KB)
- Español - ES (562 KB)
- Swedish - SV (562 KB)
- Italian - IT (562 KB)
- Korean - KR (562 KB)
- Portuguese - PT (562 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sekino K, et al. Herbicidal activity of a new paddy bleaching herbicide, benzobicyclon. Journal of Pesticide Science, 2008, 33(4): 364-370.

[2]. Williams KL, et al. Hydrolytic Activation Kinetics of the Herbicide Benzobicyclon in Simulated Aquatic Systems. J Agric Food Chem. 2016 Jun 22;64(24):4838-44. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2373 mL	11.1864 mL	22.3729 mL	55.9322 mL
	5 mM	0.4475 mL	2.2373 mL	4.4746 mL	11.1864 mL
	10 mM	0.2237 mL	1.1186 mL	2.2373 mL	5.5932 mL
	15 mM	0.1492 mL	0.7458 mL	1.4915 mL	3.7288 mL
	20 mM	0.1119 mL	0.5593 mL	1.1186 mL	2.7966 mL
	25 mM	0.0895 mL	0.4475 mL	0.8949 mL	2.2373 mL
	30 mM	0.0746 mL	0.3729 mL	0.7458 mL	1.8644 mL

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Benzobicyclon

Metabolism/Protease Compound Library

Targeted Diversity Library

Metabolic Enzyme Compound Library

Cysteine Targeted Covalent Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Environmental Pollutant Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Benzobicyclon

Metabolism/Protease Compound Library

Targeted Diversity Library

Metabolic Enzyme Compound Library

Cysteine Targeted Covalent Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Environmental Pollutant Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Benzobicyclon Related Classifications

HY-118742 Related Classifications