CHIKV-IN-3
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC50>100 μM). Prophylactic effect.
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- CAS. Nr.: 2906132-49-6
- Formel: C24H30ClNO
- Molecular Weight:383.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
EC50: 1.55 µM (CHIKV-122508); 0.14 µM (CHIKV-6708)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BHK-21 | CC50 |
>100 μM
Compound: (E)-42
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Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability
Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability
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[PMID: 35085859] |
CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 μM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC50 of 1.55 μM and demonstrates low cytotoxicity (CC50=129.6 μM)[1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 μM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa CCL2 cells, HeLa CCL2 cells infected with CHIKV-122508
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Concentration:0.1-100 µM
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Incubation Time:24 hours
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Result:Inhibited the CHIKV replication with an EC50 of 1.55 µM and demonstrated low cytotoxicity(CC50=129.6 µM)
Chemical Information
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CAS. Nr. 2906132-49-6
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Molecular Weight 383.95
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Formel C24H30ClNO
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CHIKV-IN-3 Related Classifications
HY-144334 Related Classifications
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