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Art. -Nr.: HY-143461

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CK2 inhibitor 3

CK2 inhibitor 3 is a potent CK2 inhibitor with IC₅₀ value of 280 nM. CK2 inhibitor 3 inhibits endocellular CK2, significantly affects viability of tumour cells and shows remarkable selectivity on a panel of 320 kinases.

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CAS. Nr.: 2979847-14-6
Formel: C₁₃H₉BrN₄O₃S
Molecular Weight:381.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CK2 inhibitor 3 Chemical Structure

CAS. Nr.: 2979847-14-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CK2

280 nM (IC₅₀)

Alle Casein Kinase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	DC₅₀	12.8 μM Compound: 4	Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as induction of cell death incubated for 24 hrs by MTT assay	[PMID: 32283296]

In Vitro

CK2 inhibitor 3 (compound 4) (0-50 μM; 24 hours) significantly reduces cell viability in a dose-dependent manner, and DC₅₀ value is 12.80 μM^[1].
CK2 inhibitor 3 (5 μM and 20 μM; 16 hours) decreases the CK2-dependent phospho-site Akt Ser129 level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

Jurkat cells^[1]
Concentration:

0 μM, 10 μM, 20 μM, 30 μM, 40 μM and 50 μM
Incubation Time:

24 hours
Result:

Significantly reduced cell viability in a dose-dependent manner, and DC₅₀ value was 12.80 μM.

Western Blot Analysis

Cell Line:

Jurkat cells^[1]
Concentration:

5 μM and 20 μM
Incubation Time:

16 hours
Result:

Decreased the CK2-dependent phospho-site Akt Ser129 level.

Chemical Information

CAS. Nr. 2979847-14-6
Molecular Weight 381.20
Formel C₁₃H₉BrN₄O₃S
SMILES

COC1=CC(/C=C(C(NC2=NN=C(S2)Br)=O)\C#N)=CC=C1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dalle Vedove A, Zonta F, Zanforlin E, et al. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem. 2020;195:112267. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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CK2 inhibitor 3

Alle Casein Kinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CK2 inhibitor 3 Related Classifications

HY-143461 Related Classifications