COX-2-IN-26
COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile.
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- CAS. Nr.: 2413565-19-0
- Formel: C23H21N7OS3
- Molecular Weight:507.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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COX-2 0.067 μM (IC50) |
COX-1 10.61 μM (IC50) |
15-LOX 1.96 μM (IC50) |
. COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2413565-19-0
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Molecular Weight 507.65
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Formel C23H21N7OS3
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SMILES
O=C1N(C2=CC=CC=C2)/C(SC1)=N\N=C(CNC3=NC(N4C(SC)=NC5=C4C=CC=C5)=CS3)/C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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