DGK-IN-1
Based on 1 Customer Validation
DGK-IN-1 is a DGK inhibitor (DGKa/DGKz IC50: 0.65/0.25 μM). DGK-IN-1 is a T cell activator that can be used in cancer and viral infection research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.67%
- CAS. Nr.: 2407892-34-4
- Formel: C29H27Cl2N5O
- Molecular Weight:532.46
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
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Anti-Cancer Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biologische Aktivität
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DGKa 0.65 μM (IC50) |
DGKz 0.25 μM (IC50) |
DGK-IN-1 (Example 25) activates the expression of IFNγ in human CD8+ T cells (EC50: 4.3 nM) and whole blood (EC50: 0.39 μM)[1].
DGK-IN-1 inhibits the expression of IFNγ in mouse cytotoxic T cells (CTL) (IC50: 41 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2407892-34-4
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Appearance Solid
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Molecular Weight 532.46
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Formel C29H27Cl2N5O
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Color Off-white to light yellow
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SMILES
N#CC1=NC2=C(N(C)C(C=C2N3[C@@H](C)CN(C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)[C@H](C)C3)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 5 mg/mL (9.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8781 mL | 9.3904 mL | 18.7808 mL | 46.9519 mL |
| 5 mM | 0.3756 mL | 1.8781 mL | 3.7562 mL | 9.3904 mL |
DGK-IN-1 Related Classifications
HY-135898 Related Classifications
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