EGFR-IN-63
EGFR-IN-63 is an EGFR inhibition (IC50: 0.096 μM) and it has anticancer activity in MCF-7 cells (IC50: 2.49 μM).
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- CAS. Nr.: 2414635-72-4
- Formel: C20H12BrN5S
- Molecular Weight:434.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
EGFR- IN-63 (2-4 hours) has superior EGFR inhibition (IC50 = 0.096 μM) compared to Gefitinib (IC50 = 0.166 μM)and anticancer activity against MCF-7 cell line (IC50 = 2.49 μM) compared to Gefitinib (IC50 = 4.972 μM). EGFR- IN-63 leads to pre G1 apoptosis with cell growth arrest at G2/M phase in MCF-7 cells after 24 h, the percentage of DNA content (41.45 %) shows increase compared to the control cells (7.1 %). EGFR- IN-63 arrest cell growth at G2/M phase and induces its apoptotic effect. The percentage of the total apoptotic cells in MCF-7 cell line increases after treatment with EGFR- IN-63(24.19 %) relative to control cells (1.47 %)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, MCF-7,WI38, PC9 and HCC827 cell lines
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Concentration:10% of the culture medium volume
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Incubation Time:2 - 4 hours
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Result:Displayed superior EGFR inhibitory、anticancer activity and low cytotoxicity.
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Cell Line:MCF-7
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Concentration:0.01 μM
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Incubation Time:24 hour
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Result:Led to pre G1 apoptosis with cell growth arrest at G2/M phase in MCF-7 cells.
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Cell Line:MCF-7
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Concentration:0.01 μM
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Incubation Time:24 hour
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Result:Revealed cell growth arrest at G2/M phase and inducted apoptotic effect.
Chemical Information
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CAS. Nr. 2414635-72-4
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Molecular Weight 434.31
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Formel C20H12BrN5S
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SMILES
BrC1=CC2=C(NC3=NC4=CC=CC=C4S3)N=C(C5=CC=CN=C5)N=C2C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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