Art. -Nr.: HY-N2394

Emodin-1-O-β-D-glucopyranoside

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC₅₀ of 0.85 μM.

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Reinheit: 99.79%
CAS. Nr.: 38840-23-2
Formel: C₂₁H₂₀O₁₀
Molecular Weight:432.38

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Emodin-1-O-β-D-glucopyranoside Chemical Structure

CAS. Nr.: 38840-23-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.85 μM (BNA)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	>25 μM Compound: 2	Phototoxicity against human A549 cells assessed as reduction in cell growth preincubated with compound for 24 hrs followed by blue light irradiation at 468 nm for 7 mins 30 sec and measured after 48 hrs by SRB assay Phototoxicity against human A549 cells assessed as reduction in cell growth preincubated with compound for 24 hrs followed by blue light irradiation at 468 nm for 7 mins 30 sec and measured after 48 hrs by SRB assay	[PMID: 37708055]
A549	EC₅₀	>25 μM Compound: 2	Phototoxicity against human A549 cells assessed as reduction in cell growth preincubated with compound for 24 hrs under dark condition and measured after 48 hrs by SRB assay Phototoxicity against human A549 cells assessed as reduction in cell growth preincubated with compound for 24 hrs under dark condition and measured after 48 hrs by SRB assay	[PMID: 37708055]
AGS	EC₅₀	>25 μM Compound: 2	Phototoxicity against human AGS cells assessed as reduction in cell growth preincubated with compound for 24 hrs followed by blue light irradiation at 468 nm for 7 mins 30 sec and measured after 48 hrs by SRB assay Phototoxicity against human AGS cells assessed as reduction in cell growth preincubated with compound for 24 hrs followed by blue light irradiation at 468 nm for 7 mins 30 sec and measured after 48 hrs by SRB assay	[PMID: 37708055]
AGS	EC₅₀	>25 μM Compound: 2	Phototoxicity against human AGS cells assessed as reduction in cell growth preincubated with compound for 24 hrs under dark condition and measured after 48 hrs by SRB assay Phototoxicity against human AGS cells assessed as reduction in cell growth preincubated with compound for 24 hrs under dark condition and measured after 48 hrs by SRB assay	[PMID: 37708055]
T-24	EC₅₀	>25 μM Compound: 2	Phototoxicity against human T24 cells assessed as reduction in cell growth preincubated with compound for 24 hrs followed by blue light irradiation at 468 nm for 7 mins 30 sec and measured after 48 hrs by SRB assay Phototoxicity against human T24 cells assessed as reduction in cell growth preincubated with compound for 24 hrs followed by blue light irradiation at 468 nm for 7 mins 30 sec and measured after 48 hrs by SRB assay	[PMID: 37708055]
T-24	EC₅₀	>25 μM Compound: 2	Phototoxicity against human T24 cells assessed as reduction in cell growth preincubated with compound for 24 hrs under dark condition and measured after 48 hrs by SRB assay Phototoxicity against human T24 cells assessed as reduction in cell growth preincubated with compound for 24 hrs under dark condition and measured after 48 hrs by SRB assay	[PMID: 37708055]

Chemical Information

CAS. Nr. 38840-23-2
Appearance Solid
Molecular Weight 432.38
Formel C₂₁H₂₀O₁₀
Color Light yellow to orange
SMILES

O=C1C2=C(C=C(O)C=C2O)C(C3=CC(C)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C13)=O
Structure Classification
- Quinones
- Anthraquinones
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Biomed Res Int

Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPAR α/ γ-AMPK-SIRT1 Pathway and Fatty Acid Metabolism. [Abstract]

2021 Sep 9;2021:9066938. PMID: 34540999

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (231.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3128 mL

11.5639 mL

23.1278 mL

5 mM

0.4626 mL

2.3128 mL

4.6256 mL

10 mM

0.2313 mL

1.1564 mL

2.3128 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Uddin Z, et al. Potent bacterial neuraminidase inhibitors, anthraquinone glucosides from Polygonumcuspidatum and their inhibitory mechanism. J Ethnopharmacol. 2016 Dec 4;193:283-292. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3128 mL	11.5639 mL	23.1278 mL	57.8195 mL
	5 mM	0.4626 mL	2.3128 mL	4.6256 mL	11.5639 mL
	10 mM	0.2313 mL	1.1564 mL	2.3128 mL	5.7820 mL
	15 mM	0.1542 mL	0.7709 mL	1.5419 mL	3.8546 mL
	20 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	25 mM	0.0925 mL	0.4626 mL	0.9251 mL	2.3128 mL
	30 mM	0.0771 mL	0.3855 mL	0.7709 mL	1.9273 mL
	40 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	50 mM	0.0463 mL	0.2313 mL	0.4626 mL	1.1564 mL
	60 mM	0.0385 mL	0.1927 mL	0.3855 mL	0.9637 mL
	80 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7227 mL
	100 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.5782 mL

Keywords

Emodin-1-O-β-D-glucopyranoside

1 Cited Publications

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Emodin-1-O-β-D-glucopyranoside

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Publications Citing Use of MedChemExpress (MCE) Emodin-1-O-β-D-glucopyranoside

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Emodin-1-O-β-D-glucopyranoside

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Glycoside Compound Library

Antibacterial Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Food-Sourced Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Quinones Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Emodin-1-O-β-D-glucopyranoside

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Emodin-1-O-β-D-glucopyranoside Related Classifications

Art. -Nr.: HY-N2394