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FTO-IN-14

FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC50 of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC50 for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models.

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  • Formel: C22H23N3O2S
  • Molecular Weight:393.50
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • FTO-IN-14 Chemical Structure
    FTO-IN-14 Chemical Structure
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  • FTO-IN-14 Chemical Structure
    FTO-IN-14 Chemical Structure
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  • FTO-IN-14