Hspa1b - heat shock protein family A (Hsp70) member 1B Gene

Also Known as HSP70; Hsp72; Hspa2; HSP70-1; HSP70.1; HSP70.2; Hsp70-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 108348108

Summary

Enables NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of vasoconstriction; and positive regulation of T cell mediated cytotoxicity. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and membrane raft. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract Infection. Orthologous to human HSPA1B (heat shock protein family A (HSP70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Hspa1b Products (1)

mRNA Protein Name
NM_001329896.1 NP_001316825.1 heat shock 70 kDa protein 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
9553041 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16394269 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
23000394 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
23000394 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23047067 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
22526757 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20809232 RGD
involved in response to unfolded protein IMP
IMP: Inferred from mutant phenotype
12397389 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock 70 kDa protein 1B

  • Heat shock 70 kDa protein 2

  • heat shock 70 kDa protein 1

  • heat shock 70 kDa protein 1A/1B

  • heat shock 70kD protein 1B

  • heat shock protein 1B

  • heat shock protein 70

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS19261 Hspa1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06425 HSPA1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117252 HS-72 Inhibitor / Unkown
HY-RS25750 Hspa1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa1b NCBI NCBI:3304