Kcnq3 - potassium voltage-gated channel, subfamily Q, member 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110862

Summary

Enables Calmodulin binding activity; Potassium Channel activity; and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and potassium ion transmembrane transport. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including central nervous system; midgut; retina; and rib. Used to study benign neonatal seizures. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq3 Products (1)

mRNA Protein Name
NM_152923.3 NP_690887.2 potassium voltage-gated channel subfamily KQT member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables calmodulin binding IMP
IMP: Inferred from mutant phenotype
24333508 MGI
enables calmodulin binding IPI
IPI: Inferred from physical interaction
12223552 MGI
enables potassium channel activity IGI
IGI: Inferred from genetic interaction
23716673 MGI
enables potassium channel activity IMP
IMP: Inferred from mutant phenotype
19060215 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24333508 MGI
enables voltage-gated monoatomic ion channel activity IGI
IGI: Inferred from genetic interaction
12223552 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within action potential initiation IDA
IDA: Inferred from direct assay
26312501 MGI
acts upstream of or within action potential initiation IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within action potential initiation IMP
IMP: Inferred from mutant phenotype
26733196 MGI
acts upstream of or within apoptosome assembly IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
23259949 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
23259949 MGI
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
19060215 MGI
acts upstream of or within excitatory chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
30382937 MGI
acts upstream of or within exocytosis IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within inhibitory chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
30382937 MGI
acts upstream of or within membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
19060215 MGI
acts upstream of or within mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within neuron remodeling IGI
IGI: Inferred from genetic interaction
30382937 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
24719109 MGI
acts upstream of or within potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
19060215 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within protein targeting IMP
IMP: Inferred from mutant phenotype
24333508 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
24333508 MGI
acts upstream of or within psychomotor behavior IMP
IMP: Inferred from mutant phenotype
19453707 MGI
acts upstream of or within regulation of action potential firing threshold IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within response to auditory stimulus IDA
IDA: Inferred from direct assay
26312501 MGI
acts upstream of or within response to auditory stimulus IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
26733196 MGI
acts upstream of or within response to organic cyclic compound IDA
IDA: Inferred from direct assay
20885443 MGI
acts upstream of or within sensory perception of sound IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within substantia propria of cornea development IMP
IMP: Inferred from mutant phenotype
19453707 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in axon initial segment IDA
IDA: Inferred from direct assay
14762142 MGI
located in axon initial segment IDA
IDA: Inferred from direct assay
16525039 MGI
is active in axon initial segment IMP
IMP: Inferred from mutant phenotype
24333508 MGI
is active in cell surface IDA
IDA: Inferred from direct assay
14762142 MGI
located in cell surface IDA
IDA: Inferred from direct assay
12223552 MGI
is active in node of Ranvier IDA
IDA: Inferred from direct assay
14762142 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
16525039 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16525039 MGI
part of voltage-gated potassium channel complex IGI
IGI: Inferred from genetic interaction
12223552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily KQT member 3

  • KQT-like 3

  • potassium channel subunit alpha KvLQT3

  • voltage-gated potassium channel subunit Kv7.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-108577 XE991 dihydrochloride Inhibitor / Unkown
HY-122114 ICA-27243 Activator 98.74% Unkown
HY-108577A XE991 Inhibitor 99.69% Unkown
HY-130070 QO-40 Activator 98.77% Unkown
HY-184207 Zinc13732787 Inhibitor / Unkown
HY-RS07175 KCNQ3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19700 Kcnq3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26195 Kcnq3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq3 NCBI NCBI:3786