Zinc13732787
Zinc13732787 is an inhibitor of the KCNQ1/KCNE1 potassium channel complex, with no activity against the KCNQ2/KCNQ3 channel. Zinc13732787 reduces axonal growth in human neural stem cells, while exerting no effect on KCNQ1-knockout neural stem cells. Zinc13732787 can be used for research on arrhythmia, epilepsy, and neuropsychiatric disorders.
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- CAS No.: 119486-83-8
- Formule: C23H19ClN4O2
- Masse moléculaire:418.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
KCNQ1 |
In Vitro
Zinc13732787 (1-100 μM) potently inhibits human KCNQ1/KCNE1 channels in Xenopus laevis oocytes, reducing current amplitude to 47.9% of control at 20 μM, with greater potency against KCNQ1 alone and persistent inhibition after washout[1].
Zinc13732787 (10-100 μM) does not inhibit human KCNQ2/KCNQ3 channels in Xenopus laevis oocytes at concentrations up to 100 μM[1].
Zinc13732787 (1-50 μM; 48 h) reduces neurite outgrowth in human wild-type iPSC-derived NSCs at 1, 5, and 10 μM without affecting proliferation or cytotoxicity, with no effect observed in KCNQ1-knockout NSCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 119486-83-8
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Masse moléculaire 418.88
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Formule C23H19ClN4O2
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SMILES
O=C1[C@H](NC(NC2=CC=CC(Cl)=C2)=O)N=C(C3=CC=CC=C3)C4=CC=CC=C4N1C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zinc13732787 Related Classifications
HY-184207 Related Classifications
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Keywords
- Zinc13732787
- 119486-83-8
- Zinc 13732787
- Zinc-13732787
- Potassium Channel
- Xenopus laevis oocytes
- KCNQ2/KCNQ3 channels
- KCNQ1-knockout neuronal stem cells
- cardiac arrhythmias
- human wild-type iPSC-derived NSCs
- neuropsychiatric disorders
- KCNQ1/KCNE1 potassium channel complex
- epilepsy
- human neuronal stem cells
- Inhibitor
- inhibitor
- inhibit