2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Zinc13732787

Zinc13732787 is an inhibitor of the KCNQ1/KCNE1 potassium channel complex, with no activity against the KCNQ2/KCNQ3 channel. Zinc13732787 reduces axonal growth in human neural stem cells, while exerting no effect on KCNQ1-knockout neural stem cells. Zinc13732787 can be used for research on arrhythmia, epilepsy, and neuropsychiatric disorders.

For research use only. We do not sell to patients.

Zinc13732787

Zinc13732787 Chemical Structure

CAS No. : 119486-83-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Zinc13732787 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Zinc13732787 is an inhibitor of the KCNQ1/KCNE1 potassium channel complex, with no activity against the KCNQ2/KCNQ3 channel. Zinc13732787 reduces axonal growth in human neural stem cells, while exerting no effect on KCNQ1-knockout neural stem cells. Zinc13732787 can be used for research on arrhythmia, epilepsy, and neuropsychiatric disorders[1].

IC50 & Target[1]

KCNQ1

 

In Vitro

Zinc13732787 (1-100 μM) potently inhibits human KCNQ1/KCNE1 channels in Xenopus laevis oocytes, reducing current amplitude to 47.9% of control at 20 μM, with greater potency against KCNQ1 alone and persistent inhibition after washout[1].
Zinc13732787 (10-100 μM) does not inhibit human KCNQ2/KCNQ3 channels in Xenopus laevis oocytes at concentrations up to 100 μM[1].
Zinc13732787 (1-50 μM; 48 h) reduces neurite outgrowth in human wild-type iPSC-derived NSCs at 1, 5, and 10 μM without affecting proliferation or cytotoxicity, with no effect observed in KCNQ1-knockout NSCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zinc13732787 Related Antibodies
Molecular Weight

418.88

Formula

C23H19ClN4O2
CAS No.
SMILES

O=C1[C@H](NC(NC2=CC=CC(Cl)=C2)=O)N=C(C3=CC=CC=C3)C4=CC=CC=C4N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Zinc13732787 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinc13732787119486-83-8Zinc 13732787Zinc-13732787Potassium ChannelKcsAXenopus laevis oocytesKCNQ2/KCNQ3 channelsKCNQ1-knockout neuronal stem cellscardiac arrhythmiashuman wild-type iPSC-derived NSCsneuropsychiatric disordersKCNQ1/KCNE1 potassium channel complexepilepsyhuman neuronal stem cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Zinc13732787
Cat. No.:
HY-184207
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.