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Cat. No.: HY-184207

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Zinc13732787

Zinc13732787 is an inhibitor of the KCNQ1/KCNE1 potassium channel complex, with no activity against the KCNQ2/KCNQ3 channel. Zinc13732787 reduces axonal growth in human neural stem cells, while exerting no effect on KCNQ1-knockout neural stem cells. Zinc13732787 can be used for research on arrhythmia, epilepsy, and neuropsychiatric disorders.

For research use only. We do not sell to patients.

CAS No.: 119486-83-8
Formula: C₂₃H₁₉ClN₄O₂
Molecular Weight:418.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zinc13732787 Chemical Structure

CAS No.: 119486-83-8

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

KCNQ1

In Vitro

Zinc13732787 (1-100 μM) potently inhibits human KCNQ1/KCNE1 channels in Xenopus laevis oocytes, reducing current amplitude to 47.9% of control at 20 μM, with greater potency against KCNQ1 alone and persistent inhibition after washout^[1].
Zinc13732787 (10-100 μM) does not inhibit human KCNQ2/KCNQ3 channels in Xenopus laevis oocytes at concentrations up to 100 μM^[1].
Zinc13732787 (1-50 μM; 48 h) reduces neurite outgrowth in human wild-type iPSC-derived NSCs at 1, 5, and 10 μM without affecting proliferation or cytotoxicity, with no effect observed in KCNQ1-knockout NSCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 119486-83-8
Molecular Weight 418.88
Formula C₂₃H₁₉ClN₄O₂
SMILES

O=C1[C@H](NC(NC2=CC=CC(Cl)=C2)=O)N=C(C3=CC=CC=C3)C4=CC=CC=C4N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alam KA, et al. Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells. ACS Chem Neurosci. 2026 Jun 3;17(11):2203-2218.
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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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