FEZF1 - FEZ family zinc finger 1 Gene

Also Known as FEZ; HH22; ZNF312B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 389549

About FEZF1

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:122,301,303-122,310,723 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues, 28 paralogues and is associated with 4 phenotypes. Restricted expression toward testis (RPKM 1.2).

Summary

This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

FEZF1 Products (2)

mRNA Protein Name
NM_001024613.4 NP_001019784.2 fez family zinc finger protein 1 isoform 1
NM_001160264.2 NP_001153736.1 fez family zinc finger protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEZF1 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (274 - 298)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (305 - 326)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (331 - 354)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (358 - 382)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (400 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

fez family zinc finger protein 1

  • zinc finger protein 312B

FEZF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
FEZF1 A0PJY2 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
FEZF1 A0PJY2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
FEZF1 A0PJY2 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
FEZF1 A0PJY2 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 CYSRT1 Homo sapiens A8MQ03
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
FEZF1 A0PJY2 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
FEZF1 A0PJY2 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
FEZF1 A0PJY2 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
Intra
FEZF1 A0PJY2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 22 With Or Without Anosmia

  • HH22

  • Hypogonadotropic Hypogonadism 22, With Or Without Anosmia

  • Hypogonadism, Hypogonadotropic, Type 22 With/Without Anosmia
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Pancreatic Ductal Adenocarcinoma

  • Ductal Adenocarcinoma Of The Pancreas
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

  • Idiopathic Hypogonadotropic Hypogonadism

  • HH7

  • Hypogonadism, Isolated Hypogonadotropic

  • Ihh

  • Hypogonadism, Isolated, Hypogonadotropic

  • Hypogonadotropic Hypogonadism

  • Isolated Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism 7 Without Anosmia

  • Congenital Hypogonadotropic Hypogonadism Normosmic

  • Hh

  • Klinefelter Syndrome

  • Isolated Gonadotropin Deficiency
Hypogonadotropic Hypogonadism

  • Klinefelter Syndrome

  • Klinefelter'S Syndrome

  • Xxy Syndrome

  • Xxy Trisomy

  • Hypogonadotropism

  • 47, Xxy

  • Congenital Idiopathic Hypogonadotropic Hypogonadism

  • Isolated Congenital Gonadotropin Deficiency

  • 47,Xxy Syndrome

  • 47, Xxy Syndrome

  • Klinefelters Syndrome

  • Hypogonadism

  • Klinefelter Syndrome In Males

  • Klinefelter Syndrome, Unspecified

  • Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Uterine Inversion

  • Inversion Of Uterus During Delivery
Myopathy, Myosin Storage, Autosomal Dominant

  • MSMA

  • Myopathy, Hyaline Body, Autosomal Dominant

  • Myopathy With Lysis Of Type I Myofibrils

  • Autosomal Dominant Hyaline Body Myopathy

  • Hyaline Body Myopathy Autosomal Dominant
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Sensorineural Hearing Loss

  • Sensory Hearing Loss

  • Sensorineural Deafness

  • Sensorineural Hearing Loss Disorder

  • Hearing Loss, Sensorineural

  • Central Hearing Loss

  • High Frequency Deafness

  • High Frequency Hearing Loss

  • High-Frequency Hearing Loss

  • Perceptive Deafness

  • Perceptive Hearing Loss

  • Perceptive Hearing Loss Or Deafness

  • Hearing Loss Sensorineural

  • Deafness Sensorineural

  • Hearing Loss High-Frequency

  • Hearing Loss, Central

  • Hearing Loss, High-Frequency
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04872 FEZF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FEZF1 VGNC VGNC:28959
Felis catus FEZF1 VGNC VGNC:80041
Rattus norvegicus FEZF1 RGD RGD:1560480
Macaca mulatta FEZF1 VGNC VGNC:72550
Mus musculus FEZF1 MGD MGI:1920441
Others FEZF1 NCBI