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Art. -Nr.: HY-163516

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HBV-IN-45

HBV-IN-45 is a selective and orally active HBV capsid assembly modulator with an IC₅₀ of 0.51 μM for HBcAg in HBC cells. HBV-IN-45 shows potent anti-HBV activities.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₆H₁₆N₂O₂S
Molecular Weight:300.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HBV-IN-45 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HBV-IN-45 is a selective and orally active HBV capsid assembly modulator with an IC₅₀ of 0.51 μM for HBcAg in HBC cells. HBV-IN-45 shows potent anti-HBV activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	84.29 μM Compound: 26f	Cytotoxicity against human HepG2 cells measured after 3 days by resazurin staining based analysis Cytotoxicity against human HepG2 cells measured after 3 days by resazurin staining based analysis	[PMID: 38636128]

In Vitro

HBV-IN-45 (compound 26f) inhibits the growth of HepG2 cells with a CC5₅₀ values of 84.29 μM. HBV-IN-45 also inhibits HBV DNA in HepAD38 cell supernatant with an EC₅₀ of 2.24 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HBV-IN-45 (compound 26f; 100 mg/kg; oral administration; twice daily; for 14 days) inhibits HBV DNA copy numbers in plasma, and the HBeAg and liver enzymes GPT (ALT) in mouse serum have no difference^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BALB/c mice injected with replication-competent HBV 1.3 DNA plasmid^[1]
Dosage:

100 mg/kg
Administration:

Oral administration; twice daily; for 14 days
Result:

HBV DNA copy numbers were rapidly and markedly reduced in plasma.

Chemical Information

Molecular Weight 300.38
Formel C₁₆H₁₆N₂O₂S
SMILES

COC1=CC=C(C=C1)SC2=NC3=CC=CC=C3N2CCO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kaixin Du, et al. Development of benzimidazole-based compounds as novel capsid assembly modulators for the treatment of HBV infection. Eur J Med Chem. 2024 Apr 16:271:116402. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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