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Art. -Nr.: HY-121185A

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Hexoprenaline sulfate

Hexoprenaline sulfate is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline sulfate can dilate the bronchi. Hexoprenaline sulfate can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline sulfate exhibits anti-infection and anti-inflammmation effect. Hexoprenaline sulfate can increase placental weight and blood flow. Hexoprenaline sulfate can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 32266-10-7
Formel: C₂₂H₃₄N₂O₁₀S
Molecular Weight:518.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Hexoprenaline sulfate Chemical Structure

CAS. Nr.: 32266-10-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

β-adrenoceptor

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Hexoprenaline (10 nM-1 mM) sulfate activates adenylate cyclase in isolated rat gastric mucosal cells^[2].
Hexoprenaline (10-10000 nM) sulfate increasingly stimulate 14C-Aminopyrine uptake in isolated rat gastric mucosal cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hexoprenaline (1.5 mg/kg, s.c.) sulfate significantly reduces mortality and decreases plasma proinflammatory cytokine concentrations in mice with E. coli O157:H7-induced sepsis^[4].
Hexoprenaline (0.5 mg diet, p.o., daily) sulfate increases placental weight and blood flow in blood flow^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with E. coli O157:H7-induced sepsis^[3]
Dosage:

1.5 mg/kg
Administration:

Subcutaneous injection
Result:

Reduced the mortality by 1.98-fold at 4 h and by 1.56-fold at 24 h.
Decreased plasma TNF-α, IL-1β, and IL-6 concentrations.

Chemical Information

CAS. Nr. 32266-10-7
Molecular Weight 518.58
Formel C₂₂H₃₄N₂O₁₀S
SMILES

OC(CNCCCCCCNCC(O)C1=CC=C(C(O)=C1)O)C2=CC=C(C(O)=C2)O.OS(O)(=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Schonell M, et al. Bronchodilator effect of hexoprenaline aerosol in bronchial asthma and chronic bronchitis. Med J Aust. 1977 Dec 17;2(25):828-30. [Content Brief]

[2]. Ruoff HJ, et al. Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):175-81. [Content Brief]

[3]. Zabrodskii P F. et al. The Mechanisms of the Cholinergic Anti-Inflammatory Pathway after Acute Intoxication of Organophosphorus Compounds[J]. Biomedical Journal, 2010, 1: 5.

[4]. Zabrodskii P F. et al. The influence of various drugs on mortality of mice and the concentration of proinflammatory cytokines in blood at sepsis caused by E. coli[J]. Acta scientific microbiology, 2018, 1: 11-14.

[5]. Lipshitz J, et al. Effect of long-term administration of beta 2-sympathomimetic drug in the diet-restricted pregnant rat model. Am J Obstet Gynecol. 1986 Feb;154(2):314-7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Hexoprenaline sulfate

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Hexoprenaline sulfate Related Classifications

HY-121185A Related Classifications