Laccase-IN-3
Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS.
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- Formel: C14H15FN2O
- Molecular Weight:246.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Laccase-IN-3 (25 mg/L) inhibitis the fungal activity by is 98.2% (B. dothidea), 92% (S. sclerotiorum), 93.9 % (F. graminearum), 53.1 % (B. cinerea), 59.9 % (P. capsici), 22.0 % (P. infestans), 81.5 % (P. nicotianae), respectively[1].
Laccase-IN-3 shows ECsub>50 against various fungi: 0.17 mg/L (B. dothidea), 2.55 mg/L (S. sclerotiorum), 2.03 mg/L (F. graminearum)[1].
Laccase-IN-3 (0.79-6.25 mg/L;) inhibits fungal growth by disrupting the morphology of B. dothidea[1].
Laccase-IN-3 (10-25 mg/L; 120min) disrupts cell membrane integrity and increases cell membrane permeability of B. dothidea mycelia. Laccase-IN-3 reduces the extracellular pH and destabilizes the intracellular environment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 246.28
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Formel C14H15FN2O
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SMILES
O=C([C@H]1[C@H](C2)C=C[C@H]2C1)NNC3=CC=C(F)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Laccase-IN-3 Related Classifications
HY-162488 Related Classifications
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