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Art. -Nr.: HY-12689B

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Mitapivat hemisulfate

(Synonyms: AG-348 hemisulfate)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Mitapivat hemisulfate is an orally active pyruvate kinase allosteric activator. Mitapivat hemisulfate increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat hemisulfate can be used in study of PK deficiency.

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CAS. Nr.: 2329710-91-8
Formel: C₂₄H₂₆N₄O₃S.1/2H₂SO₄
Molecular Weight:499.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Mitapivat hemisulfate Chemical Structure

CAS. Nr.: 2329710-91-8

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Beschreibung

Chemical Information

CAS. Nr. 2329710-91-8
Molecular Weight 499.60
Formel C₂₄H₂₆N₄O₃S.1/2H₂SO₄
SMILES

O=C(N1CCN(CC2CC2)CC1)C3=CC=C(NS(=O)(C4=CC=CC5=CC=CN=C54)=O)C=C3.O=S(O)(O)=O.[0.5]
Synonyms

AG-348 hemisulfate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All PK/PD Analysis

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J Sep Sci

Development and validation of stability indicating assay method for mitapivat: Identification of novel hydrolytic, photolytic, and oxidative forced degradation products employing quadrupole-time of flight mass spectrometry. [Abstract]

2024 Jul;47(14):e2400173. PMID: 39054589
Sep Sci Plus

2025 Jan 07.

Mitapivat hemisulfate purchased from MedChemExpress. Usage Cited in: Sep Sci Plus. 2025 Jan 07.

Mean plasma concentration–time profile and log-plasma concentration–time profile of Mitapivat after a single oral dose of 5 mg/kg to SD rats (each data point corresponds to mean ± S.D., n = 4).
J Mass Spectrom

Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole-Time-of-Flight (Q-TOF) Mass Spectrometry. [Abstract]

2025 May;60(5):e5126. PMID: 40195624

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kung C, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 2017 Sep 14;130(11):1347-1356. [Content Brief]

[2]. Matte A, et al. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. J Clin Invest. 2021 May 17;131(10):e144206. [Content Brief]

[3]. Rab MAE, et al. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021 Jan 1;106(1):238-249. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Mitapivat hemisulfate

3 Cited Publications

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Publications (3)
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Mitapivat hemisulfate purchased from MedChemExpress. Usage Cited in: Sep Sci Plus. 2025 Jan 07.

Customer Validation
Mean plasma concentration–time profile and log-plasma concentration–time profile of Mitapivat after a single oral dose of 5 mg/kg to SD rats (each data point corresponds to mean ± S.D., n = 4).

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Mitapivat hemisulfate

Publications Citing Use of MedChemExpress (MCE) Mitapivat hemisulfate

Biologische Aktivität

Chemical Information

Publications (3)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Mitapivat hemisulfate Related Classifications

HY-12689B Related Classifications