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Art. -Nr.: HY-107430B

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Oxythiamine chloride

(Synonyms: Hydroxythiamine chloride)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Oxythiamine (Hydroxythiamine) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation.

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CAS. Nr.: 582-36-5
Formel: C₁₂H₁₆ClN₃O₂S
Molecular Weight:301.79

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Oxythiamine chloride Chemical Structure

CAS. Nr.: 582-36-5

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Chemical Information

CAS. Nr. 582-36-5
Molecular Weight 301.79
Formel C₁₂H₁₆ClN₃O₂S
SMILES

CC1=C(CCO)SC=[N+]1CC2=CN=C(C)NC2=O.[Cl-]
Synonyms

Hydroxythiamine chloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Nat Commun

Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability. [Abstract]

2022 Oct 17;13(1):6121. PMID: 36253417
Acta Physiol

Transketolase drives the development of aortic dissection by impairing mitochondrial bioenergetics. [Abstract]

2024 Apr;240(4):e14113. PMID: 38380737
PLoS Pathog

White spot syndrome virus IE1 protein hijacks the host pentose phosphate pathway to fuel viral replication. [Abstract]

2026 Jan 27;22(1):e1013913. PMID: 41592137

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. [Content Brief]

[2]. Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. [Content Brief]

[3]. Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Oxythiamine chloride

3 Cited Publications

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Publications (3)
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Oxythiamine chloride

Publications Citing Use of MedChemExpress (MCE) Oxythiamine chloride

Biologische Aktivität

Chemical Information

Publications (3)

Reinheit & Dokumentation

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Calculators

Help & FAQs

Oxythiamine chloride Related Classifications

HY-107430B Related Classifications