pep2-SVKI
pep2-SVKI is a selective peptide inhibitor. pep2-SVKI inhibits the binding of AMPA-type glutamate receptor (GluA2) (C-terminal PDZ site) to glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1). pep2-SVKI increases the amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). pep2-SVKI can be used to study neurological diseases.
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- CAS. Nr.: 328944-75-8
- Formel: C60H93N13O18
- Molecular Weight:1284.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
pep2-SVKI (1 mM) reduces (Miniature Excitatory Postsynaptic Current) mEPSC amplitude at both −60 mV and +40 mV in the synaptic membrane of stellate cells[1].
pep2-SVKI (100 μM) causes an increase in AMPAR-mediated (Excitatory Postsynaptic Current) EPSCs in hippocampal CA1 Neurons[2].
pep2-SVKI (100 μM) prevents the expression of LTD in a (Protein Kinase C) PKC-Dependent Manner in hippocampal CA1 Neurons[2].
pep2-SVKI increases tritium release induced by exposure to 100 μM AMPA in hippocampal synaptosomes prelabeled with (radiolabeled norepinephrine) [3H]NA and potentiates the AMPA-evoked release of [3H]NA in rat hippocampal synaptosomes[3].
pep2-SVKI causes increase in the number of AMPARs exposed on the membrane in rat hippocampal synaptosomes[3].
pep2-SVKI abolishes the sensitivity to Cyclothiazide (HY-101165) of the AMPA receptors controlling [3H]NA release[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 328944-75-8
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Molecular Weight 1284.46
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Formel C60H93N13O18
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Sequence
Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Ile
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Sequence Shortening
YNVYGIESVKI
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75. [Content Brief]
[2]. Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28(3):873-86. [Content Brief]
[3]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
pep2-SVKI Related Classifications
HY-P1056 Related Classifications
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