PNR-3-82
Based on 1 Customer Validation
PNR-3-82 is a highly selective inhibitor of endonuclease G (EndoG) with an IC50 value of 0.61 μM against EndoG. As a non-competitive inhibitor, PNR-3-82 blocks EndoG-mediated DNA fragmentation. PNR-3-82 enhances the in vivo delivery efficiency of plasmid DNA and exhibits bioprotective effects against drug-related injuries and other cell/tissue damages. PNR-3-82 can be used in studies related to prostate cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.08%
- CAS. Nr.: 1424353-64-9
- Formel: C25H17N3O4S
- Molecular Weight:455.49
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Speicherung:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Prostate Cancer Compound Library
HY-L124
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biologische Aktivität
PNR-3-82 potently inhibits recombinant mouse and human EndoG with an IC50 of 0.61 μM, acting as an uncompetitive inhibitor[1].
PNR-3-82 (1 μM; 1 h) inhibits recombinant mouse and human EndoG-mediated plasmid DNA degradation in a plasmid incision assay[1].
PNR-3-82 exhibits high specificity for EndoG, is inactive against DNase II, and has no inhibitory effect on RNase A, proteases, LDH, or SOD1[1].
PNR-3-82 (50 μM; 2 h pre-incubation, followed by 24 h co-incubation with cisplatin) reduces Cisplatin (HY-17394)-induced cell death in natural EndoG-expressing 22Rv1 human prostate carcinoma cells[1].
PNR-3-82 (50 μM; 2 h pre-incubation, followed by 24 h co-incubation with docetaxel) reduces Docetaxel (HY-B0011)-induced cell death and DNA fragmentation in EndoG-overexpressing PC3 human prostate adenocarcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1424353-64-9
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Appearance Solid
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Molecular Weight 455.49
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Formel C25H17N3O4S
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Color Orange to red
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SMILES
O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(OC)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : ≥ 4.86 mg/mL (10.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1954 mL | 10.9772 mL | 21.9544 mL | 54.8859 mL |
| 5 mM | 0.4391 mL | 2.1954 mL | 4.3909 mL | 10.9772 mL | |
| 10 mM | 0.2195 mL | 1.0977 mL | 2.1954 mL | 5.4886 mL |
PNR-3-82 Related Classifications
HY-176836 Related Classifications
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