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Art. -Nr.: HY-124687

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ROMK-IN-32

ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC₅₀ of 35 nM. ROMK-IN-32 also inhibits hERG with an IC₅₀ of 22 μM.

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CAS. Nr.: 1914944-54-9
Formel: C₂₄H₂₈N₄O₅
Molecular Weight:452.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ROMK-IN-32 Chemical Structure

CAS. Nr.: 1914944-54-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC₅₀ of 35 nM. ROMK-IN-32 also inhibits hERG with an IC₅₀ of 22 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.035 μM Compound: 32	Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay Inhibition of human ROMK channel expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay	[PMID: 28431879]
HEK293	IC₅₀	21.6 μM Compound: 32	Displacement of [35S]MK499 from human ERG expressed in HEK293 cells Displacement of [35S]MK499 from human ERG expressed in HEK293 cells	[PMID: 28431879]

In Vitro

ROMK-IN-32 (compound 32) exhibits weak human SERT activity (IC₅₀ 10.4 μM; hSERT/hROMK EP=612x)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model^[1].
ROMK-IN-32 exhibits moderate oral bioavailability (78%) following oral administration (1 mg/kg) in WH rats^[1].
ROMK-IN-32 exhibits terminal elimination half-lives (rat 4.7 and dog 5.8 h) due to high plasma clearance (9.6 and 18.3 mL/min/kg respectively) combined with large volumes of distribution (3.0 and 5.0 L/kg respectively) following intravenous administration (rat 0.5 and dog 1.0 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1914944-54-9
Molecular Weight 452.50
Formel C₂₄H₂₈N₄O₅
SMILES

O=C1N(C(C=C2)=NN(C)C2=O)CCC13CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shuzhi Dong, et al. Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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