93 Results for "

DNA probe

" in MedChemExpress (MCE) Product Catalog:
Products (93)

93 Results for "DNA probe" in MCE Product Catalog:

22
Hoechst 33258
Hoechst 33258
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22 Publications Verification
Art. -Nr.: HY-15558
CAS. Nr.: 23491-44-3
Reinheit:  99.11%
Synonyms: bisBenzimide H 33258; H 33258
Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .
5
N-Methylmesoporphyrin IX
N-Methylmesoporphyrin IX
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5 Cited Publications
Art. -Nr.: HY-133821
CAS. Nr.: 142234-85-3
Reinheit:  97.83%
N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies .
4
9-Aminoacridine
9-Aminoacridine
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4 Cited Publications
Art. -Nr.: HY-B1422
CAS. Nr.: 90-45-9
Synonyms: Aminacrine
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
2
Vari Fluor 488-Phalloidin
Vari Fluor 488-Phalloidin
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2 Cited Publications
Art. -Nr.: HY-D1817
Vari Fluor 488-Phalloidin is a fluorescent derivative of Phalloidin that specifically labels myofilament proteins and exhibits green fluorescence when labeled, allowing for fluorescence imaging using FITC channels (Ex/Em=488 nm/513 nm) .
1
Thiazole Orange
Thiazole Orange
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1 Cited Publications
Art. -Nr.: HY-D0150
CAS. Nr.: 107091-89-4
Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λex = 510 nm (488 nm and 470 nm also show strong excitation) and λem = 527 nm, respectively .
1
Chromomycin A3
Chromomycin A3
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1 Cited Publications
Art. -Nr.: HY-W040129
CAS. Nr.: 7059-24-7
Category:  

Microorganisms

Target:  

DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase

Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
1
AF488 NHS ester TEA
AF488 NHS ester TEA
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1 Cited Publications
Art. -Nr.: HY-D1730A
AF488 NHS ester TEA is an amine specific fluorescence probe (λem=525 nm=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
1
Vari Fluor 555-Phalloidin
Vari Fluor 555-Phalloidin
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1 Cited Publications
Art. -Nr.: HY-D1816
Vari Fluor 555-Phalloidin is a fluorescent derivative of Phalloidin that specifically labels myofilament proteins and exhibits red fluorescence when labeled, allowing for fluorescence imaging using the PE channel (Ex/Em=550 nm/561 nm) .
1
ML367
ML367
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1 Cited Publications
Art. -Nr.: HY-122198
CAS. Nr.: 381168-77-0
Reinheit:  99.84%
Target:  

Checkpoint Kinase (Chk)

Forschungsgebiete:  

Cancer

ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation .
1
Vari Fluor 594-Phalloidin
Vari Fluor 594-Phalloidin
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1 Cited Publications
Art. -Nr.: HY-D1820
Vari Fluor 594-Phalloidin is a fluorescent derivative of Phalloidin that specifically labels myofilament proteins and exhibits red fluorescence at 585/609 nm when labeled .
1
UNC9512
UNC9512
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1 Cited Publications
Art. -Nr.: HY-156257
CAS. Nr.: 3032393-24-8
Reinheit:  98.90%
Target:  

DNA/RNA Synthesis

Forschungsgebiete:  

Cancer

UNC9512 is a selective 53BP1 inhibitor with an IC50 of 0.46 μM, and a Kd values of 0.17 μM. UNC9512 binds 53BP1 and its tandem Tudor domain, disrupts histone H4 interaction, and inhibits 53BP1 activity. UNC9512 can be used as a probe for DNA damage repair and Gene editing .
1
Coralyne chloride
Coralyne chloride
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1 Cited Publications
Art. -Nr.: HY-118581
CAS. Nr.: 38989-38-7
Reinheit:  98.30%
Target:  

Topoisomerase

Forschungsgebiete:  

Cancer

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .
1
PDD00031705
PDD00031705
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1 Cited Publications
Art. -Nr.: HY-135846
CAS. Nr.: 2032096-45-8
Reinheit:  99.47%
Target:  

Poly(ADP-ribose) Glycohydrolase (PARG)

Forschungsgebiete:  

Cancer

PDD00031705 is a benzimidazolone core cell-inactive inhibitor of Poly (ADP-ribose) glycohydrolase (PARG) .
Biotin-aniline
Biotin-aniline
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Art. -Nr.: HY-139912
CAS. Nr.: 769933-15-5
Reinheit:  99.63%
Target:  

DNA Stain Biochemical Assay Reagents

Forschungsgebiete:  

Others

Biotin-aniline is a probe with substantially high reactivity towards RNA and DNA. Biotin-aniline is also a novel APEX2 substrate. Biotin-aniline can label proteins via miniSOG. Biotin-aniline emerges as more efficient probe for capturing subcellular transcriptome in living cells with high spatial specificity .
BODIPY-FL
BODIPY-FL
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Art. -Nr.: HY-43520
CAS. Nr.: 165599-63-3
BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .
2-Aminopurine
2-Aminopurine
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Art. -Nr.: HY-W012642
CAS. Nr.: 452-06-2
2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics .
Aldehyde reactive probe TFA
Aldehyde reactive probe TFA
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Art. -Nr.: HY-135136
CAS. Nr.: 627090-10-2
Reinheit:  95.10%
Target:  

Biochemical Assay Reagents Fluorescent Dye

Forschungsgebiete:  

Others

Aldehyde reactive probe TFA is an aldehyde reactive probe. Aldehyde reactive probe TFA specifically labels the AP site in DNA with biotin residues. Aldehyde reactive probe TFA can detect RNA oxidation-induced debasement sites. Aldehyde reactive probe TFA can be used to quantify AP sites or detect other aldehyde-containing DNA damage and RNA oxidation-induced debasement sites .
Vari Fluor 633-Phalloidin
Vari Fluor 633-Phalloidin
0 Images
Art. -Nr.: HY-D1819
Vari Fluor 633-Phalloidin is a fluorescent derivative of Phalloidin that specifically labels myofilament proteins and exhibits red fluorescence at 630/650 nm when labeled .
2-Di-1-ASP
2-Di-1-ASP
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Art. -Nr.: HY-135009
CAS. Nr.: 2156-29-8
Reinheit:  99.97%
Synonyms: DASPI
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .
DeepRed Nucleus Dye
DeepRed Nucleus Dye
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Art. -Nr.: HY-D1742
CAS. Nr.: 254098-36-7
DeepRed Nucleus Dye is a novel cell permeant and far red-fluorescing DNA probe. DeepRed Nucleus Dye excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DeepRed Nucleus Dye fluorescence reflects cellular DNA content. DeepRed Nucleus Dye can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .
Assay Types