3032393-24-8
3032393-24-8
Chemical Structure
UNC9512
- CAS 番号: 3032393-24-8
- Formula:C31H34N6O3
- Molecular Weight:538.64
InChIKey: OYWGFOXQBJYTIR-DEOSSOPVSA-N
SMILES: O=C(NC1=CC(C2=CC=C(C3=C2)CNC3=O)=CC=C1)[C@H]4CCCN(C4)C(C5=NC=CC(N6CCN(CC6)C)=C5)=O
Biological Activity: UNC9512 is a selective 53BP1 inhibitor with an IC50 of 0.46 μM, and a Kd values of 0.17 μM. UNC9512 binds 53BP1 and its tandem Tudor domain, disrupts histone H4 interaction, and inhibits 53BP1 activity. UNC9512 can be used as a probe for DNA damage repair and Gene editing[1][2].
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UNC9512 | 98.90% | UNC9512 is a selective 53BP1 inhibitor with an IC50 of 0.46 μM, and a Kd values of 0.17 μM. UNC9512 binds 53BP1 and its tandem Tudor domain, disrupts histone H4 interaction, and inhibits 53BP1 activity. UNC9512 can be used as a probe for DNA damage repair and Gene editing. | ||||||||||||||||||||
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References
- [1]. Liu, J., et al. CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling. Hum Genet 136, 1-12 (2017).
- [2]. Shell DJ, et al. Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen. J Med Chem. 2023 Oct 26;66(20):14133-14149. [Content Brief]
Keywords
