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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
MPL
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "MPL" in MCE Product Catalog:
4
4 Cited Publications
Forschungsgebiete:
Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay .
Synonyms: Megakaryocytes/platelets inducing agent
Target:
Forschungsgebiete:
TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells .
Art. -Nr.: HY-P990685
CAS. Nr.: 267639-76-9
Target:
Forschungsgebiete:
Synonyms: Hetrombopag (tautomerism); SHR-8735 (tautomerism)
Forschungsgebiete:
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Art. -Nr.: HY-145589
CAS. Nr.: 2600513-51-5
Synonyms: Hetrombopag; SHR-8735
Forschungsgebiete:
Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Art. -Nr.: HY-144002
CAS. Nr.: 216014-46-9
Synonyms: RC-529
Art. -Nr.: HY-148748G
CAS. Nr.: 1110767-45-7
Art. -Nr.: HY-RS08616
Target:
Forschungsgebiete:
MPL Human Pre-designed siRNA Set A contains three designed siRNAs for MPL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-112486G
CAS. Nr.: 1429321-13-0
Synonyms: Megakaryocytes/platelets inducing agent (GMP)
Art. -Nr.: HY-159671
CAS. Nr.: 252042-59-4
Synonyms: 3D-MPL (14)
Art. -Nr.: HY-NP074
Synonyms: MPL
Art. -Nr.: HY-RS08617
Target:
Forschungsgebiete:
Mpl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS08618
Target:
Forschungsgebiete:
Mpl Rat Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P990469
Synonyms: TA136
Target:
Forschungsgebiete:
Art. -Nr.: HY-159671B
Synonyms: 3D-MPL (14) ammonium
Target:
Forschungsgebiete:
3D-Monophosphoryl Lipid (14) (3D-MPL (14)) ammonium is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
Art. -Nr.: HY-159672A
CAS. Nr.: 220048-49-7
Synonyms: 3D-MPL (12,16) free acid
Target:
Forschungsgebiete:
3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) free acid is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
Art. -Nr.: HY-159672B
Synonyms: 3D-MPL (12,16) triethylamine
Target:
Forschungsgebiete:
3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) triethylamine is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
Art. -Nr.: HY-159671A
CAS. Nr.: 252042-60-7
Synonyms: 3D-MPL (14) triethylamine
Target:
Forschungsgebiete:
3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) triethylamine is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
