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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
modifiers
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "modifiers" in MCE Product Catalog:
60
Target:
Forschungsgebiete:
Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .
60
60 Publications Verification
Art. -Nr.: HY-B0180A
CAS. Nr.: 99011-78-6
Synonyms: R 837 hydrochloride
Target:
Forschungsgebiete:
Infection Neurological Disease Inflammation/Immunology Cancer
Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19 .
60
60 Publications Verification
Art. -Nr.: HY-B0180B
CAS. Nr.: 896106-16-4
Target:
Forschungsgebiete:
Infection Neurological Disease Inflammation/Immunology Cancer
Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19 .
9
9 Cited Publications
Synonyms: RG7916; RO7034067
Target:
Forschungsgebiete:
Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .
5
5 Cited Publications
Synonyms: RO6885247
Target:
Forschungsgebiete:
RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.
5
Forschungsgebiete:
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM .
4
4 Cited Publications
Art. -Nr.: HY-W011950
CAS. Nr.: 52417-22-8
Target:
Forschungsgebiete:
Acridin-9-amine (9-Aminoacridine) hydrochloride hydrate is a mutagen and DNA modifier. Acridin-9-amine hydrochloride hydrate induces mutagenic lesions during DNA replication .
3
3 Cited Publications
Synonyms: GAP-134 Hydrochloride; ZP 1609 Hydrochloride
Target:
Forschungsgebiete:
Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect .
2
2 Cited Publications
Art. -Nr.: HY-18593
CAS. Nr.: 104723-60-6
Synonyms: 6-O-alpha-D-Maltosyl-beta-cyclodextrin
1
Target:
Efaproxiral (RSR13) is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy .
1
1 Cited Publications
Synonyms: RSR13 sodium
Target:
Efaproxiral (RSR13) sodium is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral sodium decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy .
1
1 Cited Publications
Target:
Forschungsgebiete:
MS049, a chemical probe, is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells .
1
1 Cited Publications
Target:
Forschungsgebiete:
GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. GBT1118 increases tolerance to severe hypoxia .
1
1 Cited Publications
Synonyms: PABA potassium; p-Aminobenzoic acid potassium
Target:
Forschungsgebiete:
4-Aminobenzoic acid (PABA) potassium is a modifier of catecholamine oxidation reactions. 4-Aminobenzoic acid potassium is promising for research of Parkinson's disease and hypertension .
1
1 Cited Publications
Art. -Nr.: HY-109101S
Reinheit: 98.88%
1
1 Cited Publications
Target:
Forschungsgebiete:
SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement .
1
1 Cited Publications
Art. -Nr.: HY-15929
CAS. Nr.: 14348-40-4
Synonyms: 2,4,6-Tribromo-3-hydroxybenzoic acid
1
1 Cited Publications
Art. -Nr.: HY-W127512
CAS. Nr.: 546-18-9
Target:
Forschungsgebiete:
5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
Art. -Nr.: HY-W014069
CAS. Nr.: 71310-21-9
Synonyms: 11-Thioundecanoic acid; MUA; MUDA
Art. -Nr.: HY-112624C
CAS. Nr.: 9004-54-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
