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SSO111 sodium

SSO111 sodium, a 20mer fully modified antisense oligonucleotide, targets the oncogene?HER2. SSO111 sodium induces exon 15 skipping during splicing, leading to the generation of a novel mRNA transcript that excludes exon 15. SSO111 sodium downregulated HER2 mRNA, which resulted in the inhibition of proliferation and induction of apoptosis in HER2-overexpressing tumor cells.

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  • SSO111 sodium Chemical Structure
    SSO111 sodium Chemical Structure
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  • SSO111 sodium Chemical Structure
    SSO111 sodium Chemical Structure 5'-GACCGTTGGACTCACGAGTG-3' (full-length nucleotide 2'-MOE modification and phosphorothioates )
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  • 5'-GACCGTTGGACTCACGAGTG-3' (full-length nucleotide 2'-MOE modification and phosphorothioates )