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Art. -Nr.: HY-178338

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STING agonist-47

STING agonist-47 is a STING agonist with an EC₅₀ of 0.72 μM and a K_d of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₈H₂₆O₈S₄
Molecular Weight:618.76

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STING agonist-47 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

STING agonist-47 (Compound SC2S) (0.71 μM, 24 h) activates the interferon pathway in THP-1 Lucia ISG cells^[1].
STING agonist-47 (5 μM, 0.5-4 h) treatment of THP-1 Lucia ISG cells leads to significantly increased phosphorylation levels of key STING pathway proteins (pSTING, pTBK1, pIRF3)^[1].
STING agonist-47 (25 μM, 6 h) induces IFN-β secretion in THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STING agonist-47 (Compound SC2S) (0.62 μM, immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days) inhibits tumor growth in 2-day-post-fertilization casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells^[1].
STING agonist-47 (8.6 mg/kg, intratumoral injection) inhibits tumor growth in BALB/c mice inoculated with CT26mβGUS colon cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

2-day-post-fertilization (dpf) casper or nacre mutant zebrafish xenografted with Hs578T triple-negative breast cancer cells^[1]
Dosage:

0.62 μM
Administration:

Immersion administration, daily from 1 day post-infection to 4 for 3 consecutive days
Result:

Induced tumor cell apoptosis (activates Caspase3).
Reduced tumor size and increased the number of tumor-associated macrophages (TAM).
Promoted macrophage polarization to the proinflammatory M1 phenotype (expressing TNF).

Chemical Information

Molecular Weight 618.76
Formel C₂₈H₂₆O₈S₄
SMILES

COC1=CC2=C(C=C1SCCSC3=CC4=C(SC(C(CCC(O)=O)=O)=C4)C=C3OC)C=C(S2)C(CCC(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hsu NS, et al. Tumour-specific STING agonist synthesis via a two-component prodrug system. Nat Chem. 2025 Sep 16. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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