TDI-11861
Based on 1 Customer Validation
TDI-11861 is an orally active soluble sAC inhibitor optimized and designed based on TDI-10229 (HY-132298), with an IC50 of 3.3 nM and a KD of 1.4 nM. TDI-11861 has advantages such as high affinity, slow dissociation, and good pharmacokinetics. TDI-11861 can be used for research on male contraception and related sAC pharmacology.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.35%
- CAS. Nr.: 2857049-72-8
- Formel: C22H25ClF2N6O3
- Molecular Weight:494.92
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
TDI-11861 (5.5 nM; 15 min) inhibits sAC-mediated cAMP accumulation in rat 4-4 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Route | Dose (mg/kg) | AUC0-24 h (mM-h) | Cmax (mM) | Tmax (h) | T1/2 (h) | Cl (mL/min/kg) | F (%) |
| i.v. | 2 | 0.78 | 2.5 | / | 0.93 | 94 | / |
| p.o. | 10 | 0.41 | 0.45 | 0.25 | / | / | 11 |
| p.o. | 50 | 5.46 | 6.1 | 0.25 | / | / | / |