Hnrnpk - heterogeneous nuclear ribonucleoprotein K Gene
Also Known as KBBP; NOVA; Hnrpk
Species: Mus musculus
Gene Type: protein coding
Gene ID: 15387
Summary
The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]
Hnrnpk Products (22)
| mRNA | Protein | Name |
|---|---|---|
| NM_001301340.1 | NP_001288269.1 | heterogeneous nuclear ribonucleoprotein K isoform 1 |
| NM_001301341.1 | NP_001288270.1 | heterogeneous nuclear ribonucleoprotein K isoform 1 |
| NM_001301343.1 | NP_001288272.1 | heterogeneous nuclear ribonucleoprotein K isoform 1 |
| NM_001301344.1 | NP_001288273.1 | heterogeneous nuclear ribonucleoprotein K isoform 3 |
| NM_001301345.1 | NP_001288274.1 | heterogeneous nuclear ribonucleoprotein K isoform 4 |
| NM_001360490.1 | NP_001347419.1 | heterogeneous nuclear ribonucleoprotein K isoform 2 |
| NM_001360491.1 | NP_001347420.1 | heterogeneous nuclear ribonucleoprotein K isoform 5 |
| NM_001360493.1 | NP_001347422.1 | heterogeneous nuclear ribonucleoprotein K isoform 6 |
| NM_001360494.1 | NP_001347423.1 | heterogeneous nuclear ribonucleoprotein K isoform 3 |
| NM_001360495.1 | NP_001347424.1 | heterogeneous nuclear ribonucleoprotein K isoform 4 |
| NM_025279.3 | NP_079555.1 | heterogeneous nuclear ribonucleoprotein K isoform 2 |
| NM_001301340.1 | NP_001288269.1 | heterogeneous nuclear ribonucleoprotein K isoform 1 |
| NM_001301341.1 | NP_001288270.1 | heterogeneous nuclear ribonucleoprotein K isoform 1 |
| NM_001301343.1 | NP_001288272.1 | heterogeneous nuclear ribonucleoprotein K isoform 1 |
| NM_001301344.1 | NP_001288273.1 | heterogeneous nuclear ribonucleoprotein K isoform 3 |
| NM_001301345.1 | NP_001288274.1 | heterogeneous nuclear ribonucleoprotein K isoform 4 |
| NM_001360490.1 | NP_001347419.1 | heterogeneous nuclear ribonucleoprotein K isoform 2 |
| NM_001360491.1 | NP_001347420.1 | heterogeneous nuclear ribonucleoprotein K isoform 5 |
| NM_001360493.1 | NP_001347422.1 | heterogeneous nuclear ribonucleoprotein K isoform 6 |
| NM_001360494.1 | NP_001347423.1 | heterogeneous nuclear ribonucleoprotein K isoform 3 |
| NM_001360495.1 | NP_001347424.1 | heterogeneous nuclear ribonucleoprotein K isoform 4 |
| NM_025279.3 | NP_079555.1 | heterogeneous nuclear ribonucleoprotein K isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA binding |
IDA
IDA: Inferred from direct assay
|
20548952 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9185665 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within negative regulation of mRNA splicing, via spliceosome |
IMP
IMP: Inferred from mutant phenotype
|
23636947 | MGI |
| acts upstream of or within positive regulation of transcription by RNA polymerase II |
IGI
IGI: Inferred from genetic interaction
|
24530304 | MGI |
| acts upstream of or within regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
IMP
IMP: Inferred from mutant phenotype
|
20673990 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasmic stress granule |
IDA
IDA: Inferred from direct assay
|
27430620 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
heterogeneous nuclear ribonucleoprotein K |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(4)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-135691 | hnRNPK-IN-1 | 97.0% | Unkown | |
| HY-RS06273 | HNRNPK Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS21137 | Hnrnpk Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS27655 | Hnrnpk Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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