H1-0 - H1.0 linker histone Gene

Also Known as H10; H1.0; H1F0; H1FV

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3005

About H1-0

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,805,229-37,807,432 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

H1-0 Products (1)

mRNA Protein Name
NM_005318.4 NP_005309.1 histone H1.0

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
15911621 GOA
enables nucleosome binding IPI
IPI: Inferred from physical interaction
35377618 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9499053 GOA
Biological Process GO Annotation Evidence References Source
involved in heterochromatin formation IGI
IGI: Inferred from genetic interaction
19158276 GOA
involved in positive regulation of transcription regulatory region DNA binding IMP
IMP: Inferred from mutant phenotype
19158276 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
19882353 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
15911621 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21383955 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
19158276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-0 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (25 - 97)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

histone H1.0

  • H1 histone family member 0

H1-0 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H1-0 P07305 H2BC21 Homo sapiens Q16778
Anti Tag CoIP
35271311
Intra
H1-0 P07305 H2BC21 Homo sapiens Q16778
Crosslink
30021884
Intra
H1-0 P07305 H2AC21 Homo sapiens Q8IUE6
Anti Tag CoIP
35271311
Intra
H1-0 P07305 H2AC14 Homo sapiens Q99878
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H1-0 Proteins

Cat. No. Product Name Accession Purity
HY-P74887 Histone H1 Protein, Human (His) P07305-1 (M1-K194) ≥ 90%, as determined by reducing SDS-PAGE.

H1-0 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80157 Histone H1.0 Antibody (YA384) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Hyperoxaluria, Primary, Type I

  • Primary Hyperoxaluria Type 1

  • HP1

  • Glycolic Aciduria

  • Alanine-Glyoxylate Aminotransferase Deficiency

  • Hepatic Agt Deficiency

  • Oxalosis I

  • Primary Hyperoxaluria, Type I

  • Serine:Pyruvate Aminotransferase Deficiency

  • Hyperoxaluria, Primary, Type 1

  • Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

  • Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

  • Serine Pyruvate Aminotransferase Deficiency

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Oxalosis 1

  • Hyperoxaluria Primary 1

  • Hyperoxaluria Primary Type I

  • Ph1

  • Primary Hyperoxaluria Type I

  • Oxalosis Type 1

  • 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

  • Hyperoxaluria

  • Hyperoxaluria, Primary

  • Oxalosis

  • Primary Oxalosis

  • Congenital Oxaluria

  • D-Glycerate Dehydrogenase Deficiency

  • Glyceric Aciduria

  • Glycolic Aciduria

  • Hepatic Agt Deficiency

  • Oxaluria, Primary

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Primary Oxaluria

  • Hyperoxaluria Primary

  • Primary Hyperoxaluria Type 2

  • Primary Hyperoxaluria, Type I
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Alpha-Thalassemia

  • Alpha Thalassemia

  • Alpha Thalassaemia

  • Alpha Plus Thalassemia

  • Thalassemia, Alpha-

  • Thalassemias, Alpha-

  • A-Thalassemia

  • Α-Thalassemia

  • A-THAL

  • Thalassemia

  • Alpha Thalassaemia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5831 Biotin-H10 Inhibitor 98.94% Unkown
HY-117889 PARP14 inhibitor H10 99.46% Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-P11614 LCA-H10 / Unkown
HY-P11760 HER2-targeted peptide H10 Ligand / Unkown
HY-RS05944 H1-0 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus H1-0 VGNC VGNC:84027
Mus musculus H1-0 MGD MGI:95893
Rattus norvegicus H1-0 RGD RGD:2777
Bos taurus H1-0 VGNC VGNC:83619
Macaca mulatta H1-0 VGNC VGNC:109666
Others H1-0 NCBI