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Art. -Nr.: HY-P11760

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HER2-targeted peptide H10

HER2-targeted peptide H10 is a HER2-targeting peptide with a K_d value of 30.4 nM. HER2-targeted peptide H10 specifically accumulates in HER2-positive tumor tissues of xenograft mice, when conjugated with nanoparticles. HER2-targeted peptide H10 can be used for studies related to HER2-positive breast cancer.

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CAS. Nr.: 1802710-54-8
Formel: C₅₀H₈₃N₁₇O₁₂
Molecular Weight:1114.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

HER2-targeted peptide H10 Chemical Structure

CAS. Nr.: 1802710-54-8

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Beschreibung

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In Vitro

The HER2-targeted peptide H10 (H10) (5.0 × 10^-5 M; 30 min at 4 °C) specifically binds to SKBR-3 cells with high HER2 expression, but does not bind to 293A cells with low HER2 expression; this binding activity completely disappears in SKBR-3 cells with downregulated HER2 expression^[1].
The HER2-targeted peptide H10 (0.1-100 μM) exhibits low cytotoxicity, with cell survival rates approaching 100% across the concentration range of 0.1 μM to 100 μM in the tested cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

human breast cancer SKBR-3 cells, human embryonic kidney 293A cells, HER2-downregulated RNAi SKBR-3 cells
Concentration:

5.0 × 10^-5 M (FITC-labeled H10); 1 mM (Hoechst 33342)
Incubation Time:

30 min (at 4 °C)
Result:

Showed strong green fluorescence signal on the membrane of SKBR-3 cells, but no significant binding to 293A cells.
Drastically reduced green fluorescence signal in HER2-downregulated RNAi SKBR-3 cells.
Measured a 53.32% binding rate of FITC-H10 to SKBR-3 cells via flow cytometry.

In Vivo

HER2-targeted peptide H10 (2 μM; i.v.; single dose)-conjugated quantum dots exhibit specific accumulation in HER2-positive breast cancer xenografts in nude mice, with high tumor fluorescence intensity and favorable biodistribution relative to non-targeted quantum dots^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice (8-week-old female)^[1]
Dosage:

2 μM
Administration:

i.v.; single dose
Result:

Showed specific accumulation at the tumor site in in vivo imaging.
Confirmed high fluorescence intensity in tumor tissue, with relatively lower accumulation in liver and spleen compared to H6-Qdot705.
Reached quantitative ex vivo fluorescence intensity of ~65,000 ×10⁶ photons/cm²/s in tumors.

Chemical Information

CAS. Nr. 1802710-54-8
Molecular Weight 1114.30
Formel C₅₀H₈₃N₁₇O₁₂
Sequence

Lys-Leu-Arg-Leu-Glu-Trp-Asn-Arg
Sequence Shortening

KLRLEWNR
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wang Z, et al. Microarray based screening of peptide nano probes for HER2 positive tumor. Anal Chem. 2015;87(16):8367-8372. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HER2-targeted peptide H10

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