2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
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  4. HER2-targeted peptide H10

HER2-targeted peptide H10 is a HER2-targeting peptide with a Kd value of 30.4 nM. HER2-targeted peptide H10 specifically accumulates in HER2-positive tumor tissues of xenograft mice, when conjugated with nanoparticles. HER2-targeted peptide H10 can be used for studies related to HER2-positive breast cancer.

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HER2-targeted peptide H10

HER2-targeted peptide H10 Chemical Structure

CAS No. : 1802710-54-8

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HER2-targeted peptide H10 Related Antibodies

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Description

HER2-targeted peptide H10 is a HER2-targeting peptide with a Kd value of 30.4 nM. HER2-targeted peptide H10 specifically accumulates in HER2-positive tumor tissues of xenograft mice, when conjugated with nanoparticles. HER2-targeted peptide H10 can be used for studies related to HER2-positive breast cancer[1].

In Vitro

The HER2-targeted peptide H10 (H10) (5.0 × 10-5 M; 30 min at 4 °C) specifically binds to SKBR-3 cells with high HER2 expression, but does not bind to 293A cells with low HER2 expression; this binding activity completely disappears in SKBR-3 cells with downregulated HER2 expression[1].
The HER2-targeted peptide H10 (0.1-100 μM) exhibits low cytotoxicity, with cell survival rates approaching 100% across the concentration range of 0.1 μM to 100 μM in the tested cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HER2-targeted peptide H10 Related Antibodies

Immunofluorescence[1]

Cell Line: human breast cancer SKBR-3 cells, human embryonic kidney 293A cells, HER2-downregulated RNAi SKBR-3 cells
Concentration: 5.0 × 10-5 M (FITC-labeled H10); 1 mM (Hoechst 33342)
Incubation Time: 30 min (at 4 °C)
Result: Showed strong green fluorescence signal on the membrane of SKBR-3 cells, but no significant binding to 293A cells.
Drastically reduced green fluorescence signal in HER2-downregulated RNAi SKBR-3 cells.
Measured a 53.32% binding rate of FITC-H10 to SKBR-3 cells via flow cytometry.
In Vivo

HER2-targeted peptide H10 (2 μM; i.v.; single dose)-conjugated quantum dots exhibit specific accumulation in HER2-positive breast cancer xenografts in nude mice, with high tumor fluorescence intensity and favorable biodistribution relative to non-targeted quantum dots[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (8-week-old female)[1]
Dosage: 2 μM
Administration: i.v.; single dose
Result: Showed specific accumulation at the tumor site in in vivo imaging.
Confirmed high fluorescence intensity in tumor tissue, with relatively lower accumulation in liver and spleen compared to H6-Qdot705.
Reached quantitative ex vivo fluorescence intensity of ~65,000 ×106 photons/cm2/s in tumors.
Molecular Weight

1114.30

Formula

C50H83N17O12
CAS No.
Sequence

Lys-Leu-Arg-Leu-Glu-Trp-Asn-Arg
Sequence Shortening

KLRLEWNR
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Purity & Documentation
References
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HER2-targeted peptide H10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HER2-targeted peptide H101802710-54-8EGFREpidermal growth factor receptorErbB-1HER1nude miceHER2-positive tumor tissuesHER2293A cellsHER2-positive breast cancerSKBR-3 cellsHER2-targeting peptideInhibitorinhibitorinhibit

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