Lck - LCK proto-oncogene, Src family tyrosine kinase Gene

Also Known as Lck1; Lcktkr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313050

Summary

Enables antigen binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of uterine smooth muscle contraction; protein phosphorylation; and response to hydrogen peroxide. Located in endocytic vesicle; membrane raft; and plasma membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study allergic conjunctivitis and human immunodeficiency virus infectious disease. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human Lck (Lck proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lck Products (1)

mRNA Protein Name
NM_001100709.1 NP_001094179.1 proto-oncogene tyrosine-protein kinase LCK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables antigen binding IPI
IPI: Inferred from physical interaction
18178839 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
11034334 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
8104794 RGD
Biological Process GO Annotation Evidence References Source
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11034334 RGD
involved in positive regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
19208792 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11034334 RGD
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
9325251 RGD
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
19208792 RGD
involved in response to metal ion IDA
IDA: Inferred from direct assay
11477538 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
14652378 RGD
Cellular Component GO Annotation Evidence References Source
located in endocytic vesicle IDA
IDA: Inferred from direct assay
9116282 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14529711 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: Inferred from direct assay
14529711 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase LCK

  • lymphocyte cell-specific protein-tyrosine kinase

  • lymphocyte protein tyrosine kinase

  • lymphocyte-specific protein tyrosine kinase

  • p56-LCK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132166 Velzatinib Inhibitor 99.40% Unkown
HY-13561 AZM475271 Inhibitor 99.89% Unkown
HY-107447 N-Deshydroxyethyl Dasatinib Ligand 97.19% Unkown
HY-112291 SB 220025 Inhibitor 99.90% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.73% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-180888 Lck-IN-5 Inhibitor 98.09% Unkown
HY-118105 RK-20448 Inhibitor 99.38% Unkown
HY-175463 LCK degrader-2 Degrader / Unkown
HY-112448 Lck-IN-6 Inhibitor / Unkown
HY-175281 SJ11646 Degrader / Unkown
HY-175916 LCK ligand-1 Ligand / Unkown
HY-12299G WH-4-023 (GMP) Inhibitor / Unkown
HY-180928 LCK degrader-3 Degrader / Unkown
HY-179948 BTK-IN-45 Inhibitor / Unkown
HY-114980 BMS-279700 Inhibitor / Unkown
HY-163278 Lck-IN-2 Inhibitor / Unkown
HY-175437 MRT-7612 Degrader / Unkown
HY-175193 N-Deshydroxyethyl Dasatinib-C3-NH2 Inhibitor / Unkown
HY-176194 Antifibrotic agent 1 Inhibitor / Unkown
HY-133184 Aminogenistein Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown
HY-120622 BMS-243117 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lck NCBI NCBI:3932