WH-4-023 (GMP)

WH-4-023 (GMP) (>30 passages) supports long-term undifferentiated maintenance of doxycycline-independent porcine induced pluripotent stem cells (pEPSC^iPS) when included in pEPSCM, with cells retaining pluripotency marker expression matching porcine blastocysts through >30 passages^[1].
WH-4-023 (GMP) is required to maintain pluripotency factor expression in porcine and human expanded potential stem cells, though it supports lower pluripotency gene expression in hEPSCs than the alternative SRC inhibitor A419259 (HY-15764)^[1].
WH-4-023 (GMP) (48 h) inhibits ERRα protein expression and suppresses activation of the Src/Erk signaling cascade in PC-9, PC-9/GR, H1975, and PC-9/OR human NSCLC cell lines^[2].
WH-4-023 (GMP) (48 h) inhibits SP1 nuclear translocation in PC-9, PC-9/GR, H1975, and PC-9/OR human NSCLC cell lines^[2].
WH-4-023 (GMP) downregulates ERRα mRNA expression in PC-9, PC-9/GR, H1975, and PC-9/OR human NSCLC cell lines^[2].
WH-4-023 (GMP) (0.3 μM; 50+ passages) enables establishment and long-term maintenance of pESC-FIW cells (derived from in vitro porcine blastocysts) with enhanced proliferation, single-cell clonal efficiency, and stable pluripotency, while preventing EMT-associated spontaneous differentiation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.