LCK degrader-2
LCK degrader-2 is a selective CRBN-dependent molecular glue degrader targeting LCK. LCK degrader-2 induces the proximity effect between LCK and CRBN, stabilizes the CRBN-LCK ternary complex, and triggers the ubiquitination and degradation of LCK. LCK degrader-2 can be used for the research of acute lymphoblastic leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3095032-50-8
- Formula: C25H24N4O4
- Molecular Weight:444.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Lck |
LCK degrader-2 (Compound 17) (5 µM) is a molecular glue that selectively stabilizes the CRBN-LCK ternary complex; in ASMS analysis using purified compounds, it shows a relative enrichment factor of 2.4-fold and does not stabilize the CRBN-GSPT1 ternary complex[1].
LCK degrader-2 induces the proximity between recombinant CRBN and LCK in AlphaScreen assays, with an EC50 in the double-digit nM range; at concentrations above 1×10-8 M, it reduces LCK protein levels to nearly undetectable levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3095032-50-8
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Molecular Weight 444.48
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Formula C25H24N4O4
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SMILES
O=C(C(N1)=C(C)C2=C1C(C)=CC(C)=C2)NC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LCK degrader-2 Related Classifications
HY-175463 Related Classifications
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