LCK degrader-2
LCK degrader-2 is a selective CRBN-dependent molecular glue degrader targeting LCK. LCK degrader-2 induces the proximity effect between LCK and CRBN, stabilizes the CRBN-LCK ternary complex, and triggers the ubiquitination and degradation of LCK. LCK degrader-2 can be used for the research of acute lymphoblastic leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3095032-50-8
- 分子式: C25H24N4O4
- 分子量:444.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Lck |
体外実験
LCK degrader-2 induces the proximity between recombinant CRBN and LCK in AlphaScreen assays, with an EC50 in the double-digit nM range; at concentrations above 1×10-8 M, it reduces LCK protein levels to nearly undetectable levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3095032-50-8
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分子量 444.48
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分子式 C25H24N4O4
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SMILES
O=C(C(N1)=C(C)C2=C1C(C)=CC(C)=C2)NC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LCK degrader-2 関連分類
HY-175463 関連分類
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