MINPP1 - multiple inositol-polyphosphate phosphatase 1 Gene

Also Known as MIPP; PCH16; HIPER1; MINPP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9562

About MINPP1

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:87,504,893-87,553,461 (from NCBI)

This gene has 4 transcripts (splice variants), 301 orthologues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.4), adrenal (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

MINPP1 Products (3)

mRNA Protein Name
NM_001178117.2 NP_001171588.1 multiple inositol polyphosphate phosphatase 1 isoform 2 precursor
NM_001178118.2 NP_001171589.1 multiple inositol polyphosphate phosphatase 1 isoform 3
NM_004897.5 NP_004888.2 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bisphosphoglycerate 3-phosphatase activity IDA
IDA: Inferred from direct assay
18413611 GOA
enables inositol bisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol pentakisphosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
33257696 GOA
enables inositol trisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
NOT enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-hexakisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
36589890 GOA
enables inositol-hexakisphosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
33257696 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of intracellular monoatomic cation homeostasis IMP
IMP: Inferred from mutant phenotype
33257696 GOA
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IMP
IMP: Inferred from mutant phenotype
33257696 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MINPP1 Protein Structure

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (82 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
Protein Preferred Names Protein Names

multiple inositol polyphosphate phosphatase 1

  • 2,3-BPG phosphatase

MINPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MINPP1 Q9UNW1 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
MINPP1 Q9UNW1 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MINPP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70937 MINPP1 Protein, Human (HEK293, His) Q9UNW1 (S31-L487) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71854 MINPP1 Protein, Human (P.pastoris, His) Q9UNW1 (S31-L487) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 16

  • PCH16

  • Pontocerebellar Hypoplasia Type 16

  • Pontocerebellar Hypoplasia 16

  • Doid:0112333
Thyroid Cancer, Nonmedullary, 2

  • Thyroid Carcinoma, Follicular

  • Follicular Thyroid Carcinoma

  • NMTC2

  • Thyroid Cancer, Follicular

  • Thyroid Carcinoma, Follicular, Somatic

  • Ftc

  • Thyroid Cancer, Non-Medullary, 2

  • Thyroid Follicular Carcinoma

  • Follicular Thyroid Cancer

  • Cancer, Thyroid, Nonmedullary, Type 2

  • Thyroid Gland Adenocarcinoma

  • Follicular Carcinoma Of Unspecified Site

  • Moderately Differentiated Follicular Carcinoma Of Thyroid Gland

  • Pure Follicle Carcinoma Of Thyroid Gland

  • Pure Follicle Follicular Carcinoma Of Unspecified Site

  • Pure Follicular Carcinoma Of Thyroid Gland

  • Trabecular Follicular Carcinoma Of Thyroid Gland

  • Trabecular Follicular Carcinoma Of Unspecified Site

  • Well Differentiated Follicular Carcinoma Of Unspecified Site

  • Well Differentiated Follicular Carcinoma Of Thyroid Gland
Pontocerebellar Hypoplasia, Type 7

  • Pontocerebellar Hypoplasia Type 7

  • PCH7

  • Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome

  • Pontocerebellar Hypoplasia 7

  • Hypoplasia, Pontocerebellar, Type 7
Non-Syndromic Pontocerebellar Hypoplasia

  • Pontoneocerebellar Hypoplasia

  • Pch

  • Pontoneocerebellar Atrophy
Pontocerebellar Hypoplasia

  • Pch

  • Congenital Pontocerebellar Hypoplasia

  • Opch

  • Hypoplasia, Pontocerebellar

  • Pontoneocerebellar Hypoplasia

  • Nonsyndromic Pontocerebellar Hypoplasia
Familial Papillary Or Follicular Thyroid Carcinoma

  • Fnmtc

  • Familial Pure Nonmedullary Thyroid Carcinoma

  • Familial Nonmedullary Thyroid Gland Carcinoma
Lipoid Proteinosis Of Urbach And Wiethe

  • Lipoid Proteinosis

  • Urbach-Wiethe Disease

  • Hyalinosis Cutis Et Mucosae

  • Lipid Proteinosis

  • Lipoproteinosis

  • Urbach Wiethe Disease

  • Lipoglycoproteinosis

  • Lipoidosis Cutis Et Mucosae

  • Lipoidproteinosis

  • Urbach-Wiethe Lipoid Proteinosis

  • Urbach-Wiethe Syndrome

  • LIP

  • Proteinosis Lipoid
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08457 MINPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21155 Minpp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27671 Minpp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MINPP1 VGNC VGNC:74871
Canis familiaris MINPP1 VGNC VGNC:59061
Bos taurus MINPP1 VGNC VGNC:31480
Mus musculus MINPP1 MGD MGI:1336159
Rattus norvegicus MINPP1 RGD RGD:3089
Others MINPP1 NCBI