Human UGT1A10
Human UGT1A10 is a UDP-glucuronosyltransferase. UGT1A10 catalyzes the glucuronidation of Mycophenolic acid (HY-B0421). Human UGT1A10 mediates glucuronidation modification of 34 out of 42 tested bioflavonoids. Human UGT1A10 is applicable to relevant research on colorectal cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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UGT1A10 |
When expressed in COS-7 cells, UGT1A10 (30 min) efficiently glucuronidates Mycophenolic acid (HY-B0421), with an apparent Km value of 34 μM and a Vmax value of 0.63 nmole/min/mg protein, producing multiple glucuronide products[1].
His-tagged UGT1A10 (UGT1A10-H) exhibits high glucuronidation activity towards 9 different substrates[2].
Human UGT1A10 can glucuronidate 34 out of the 42 tested bioflavonoids, with a typical activity range of 3 to 14 nmol min-1 mg-1 protein. This enzyme exhibits preferential activity toward substrates with hydroxyl groups at specific ring positions, while showing reduced or no activity toward glycosylated substrates[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Human UGT1A10]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mojarrabi B, et al. The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid. Biochemical and biophysical research communications. 1997 Sep 29;238(3):775-8. [Content Brief]
[2]. Troberg J, et al. UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?. Molecular pharmaceutics. 2017 Sep 05;14(9):2875-2883. [Content Brief]
[3]. Lewinsky RH, et al. Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships. Xenobiotica; the fate of foreign compounds in biological systems. 2005 Feb;35(2):117-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Human UGT1A10 Related Classifications
HY-E72112 Related Classifications
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