MU1700
MU1700, a chemical probe, is an orally active and potent ALK1/2 inhibitor with IC50s of 13 nM and 6 nM, respectively. MU1700 shows cell membrane permeability and high brain permeability.
For research use only. We do not sell to patients.
- CAS No.: 3055312-41-6
- Formula: C26H22N4O
- Molecular Weight:406.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
ALK2 6 nM (IC50) |
ALK1 13 nM (IC50) |
ALK6 41 nM (IC50) |
MU1700 (0.1-50 μM; 24 h) shows cytotoxic effect at above 2.5 µM in U2OS cells[1].
MU1700 (0-10 μM) inhibits ALK2 catalysed phosphorylation of SMAD1/5/8[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U2OS cells
-
Concentration:0.1-50 μM
-
Incubation Time:24 h
-
Result:Showed cytotoxic effect above 2.5 µM concentration significantly.
| Dose | 20 mg/kg |
| Bioavailability | 79 % |
| Cl (ml/min/kg) | 30 (IV) |
| T1/2 | 2.5 h |
| Cmax (PO) | 3697 nM |
| Cbrain/Cplasma (4h, 100 mg/kg) | 25 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3055312-41-6
-
Molecular Weight 406.48
-
Formula C26H22N4O
-
SMILES
N1(C2=CC=C(C3=CC(OC=C4C5=C(C=CC=C6)C6=NC=C5)=C4N=C3)C=C2)CCNCC1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MU1700 Related Classifications
HY-148246 Related Classifications
Powered by Bioz